Bryostatin 3 is one of a series of cyclic macrolides isolated from the marine bryozoan Bugula neritina (Order Cheilostomata), and a potent modulator of Protein Kinase C (PKC).
Bryostatin 3, unlike Bryostatin 1, has not been extensively studied for its bioactivity. It was originally isolated from B. neritina based on its antineoplastic activity. It shows phorbol dibutyrate receptor displacement activity similar to that of Bryostatin 1. The bryostatins are known to bind and activate Protein Kinase C (PKC), though they differ from other phorbol ester tumor promoters in that they act as agonists or antagonists of PKC activity. Bryostatin 3 was found to act as an antagonist to phorbol ester tumor promoter TPA, preventing the inhibition of GH4 cell proliferation, similar to what has been observed in Bryostatin 1. Unlike Bryostatin 1, Bryostatin 3 also enhanced cell-substratum adhesion and did not block the increased adhesion observed from TPA.
|Product Type:||Small Molecule|
|Format:||White crystalline solid|
|Purity:||>80 % determined by HPLC|
|Solubility:||Soluble in methanol and ethanol|
|Stability:||Stable as a solid over extended period at -20C.|
|Storage:||-20C, avoid exposure to oxygen and direct sunlight|
Bryostatin 3 HPLC Chromatogram.
Purification Notes: Purified using near-critical and supercritical fluids as an alternate to conventional organic solvents during a sequence of phase extraction and chromatographic purification steps.
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