Hyperforin and adhyperforin are extracted from the flowers and buds of Hypericum perforatum (St. John's Wort) utilizing patented SuperFluids CXP technology [Castor, US Patent].
Adhyperforin dicyclohexylammonium salt (Adhyperforin DCHA) is a stable salt of adhyperforin, one of the active constituents responsible for the antidepressant and anxiolytic properties of extracts of St. John's Wort. Adhyperforin, like hyperforin, acts as a reuptake inhibitor of serotonin and other monoamines including norepinephrine, dopamine, and GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.
|Product Type:||Small Molecule|
|Chemical Formula:||C36H54O4, C12H23N|
|Format:||White to off-white crystalline solid|
|Purity:||>95 % determined by HPLC; <2 % Hyperforin by HPLC|
|Solubility:||Soluble in methanol and ethanol|
|Stability:||Studies have not been conducted on Adhyperforin DCHA. It should be similar to Hyperforin DCHA, which shows no decomposition after 60 days at 43C.|
|Storage:||5C, avoid exposure to oxygen and direct sunlight|
Adhyperforin DCHA HPLC Chromatogram.
Purification Notes: Initial silica chromatography separates oils and polar components from hyperforin and adhyperforin. Then C18 chromatography is used to separate hyperforin and adhyperforin. Hyperforin is in greater quantity and in the reversed phase system, hyperforin leads the adhyperforin. This means that the initial fractions will be hyperforin devoid of adhyperforin, and the later fractions will be adhyperforin contaminated with low levels of hyperforin. Adhyperforin is then purified and stabilized by the formation of the dicyclohexylammonium salt.
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