Polycomb group protein Psc Antibodies
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These IgG2a mouse monoclonal antibodies were generated against the homology region (aa535-855) of D. melanogaster Posterior Sex Combs (PSC), and recognize Drosophila PSC and the Mouse homolog, BMI-1/BMI-2.
Highlights:
- Reacts with Drosophila PSC and the Mouse homolog, BMI-1/BMI-2
- Suitable for Western Blot applications
Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies. These proteins can remodel chromatin such that epigenetic silencing of genes takes place. In mammals Polycomb Group gene expression is important in many aspects of development (homeotic gene regulation and X chromosome inactivation). Overexpression of PcG proteins correlates with the severity and invasiveness of several cancer types. The Posterior Sex Combs (Psc) gene of Drosophila is a Polycomb group (Pc-G) gene. It has been studied at a molecular level due to it being required for the maintenance of segmental determination, and because it is the Drosophila homolog of the murine bmi-1 oncogene. The Bmi1 polycomb ring finger protein promotes neural stem cell self-renewal.
From a laboratory at University of Virginia.
These IgG2a mouse monoclonal antibodies were generated against the homology region (aa535-855) of D. melanogaster Posterior Sex Combs (PSC), and recognize Drosophila PSC and the Mouse homolog, BMI-1/BMI-2.
Highlights:
- Reacts with Drosophila PSC and the Mouse homolog, BMI-1/BMI-2
- Suitable for Western Blot applications
Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies. These proteins can remodel chromatin such that epigenetic silencing of genes takes place. In mammals Polycomb Group gene expression is important in many aspects of development (homeotic gene regulation and X chromosome inactivation). Overexpression of PcG proteins correlates with the severity and invasiveness of several cancer types. The Posterior Sex Combs (Psc) gene of Drosophila is a Polycomb group (Pc-G) gene. It has been studied at a molecular level due to it being required for the maintenance of segmental determination, and because it is the Drosophila homolog of the murine bmi-1 oncogene. The Bmi1 polycomb ring finger protein promotes neural stem cell self-renewal.
From a laboratory at University of Virginia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Polycomb group protein Psc |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 1F4-E1-E2 or 6E8-E6-A8 |
| Reactivity: | Drosophila, mouse |
| Immunogen: | Homology region (aa535-855) of D. melanogaster Posterior Sex Combs (PSC) |
| Species Immunized: | Mouse |
| Buffer: | PBS, 0.05% Sodium Azide |
| Tested Applications: | WB |
| Storage: | -20C |
| Shipped: | Dry Ice |
- Martin EC, Adler PN. The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein. Development. 1993 Feb;117(2):641-55. doi: 10.1242/dev.117.2.641. PMID: 7687213.
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