Hepatitis Delta Virus (HDV), Pan-Genotypic Antibodies
![Anti-Hepatitis Delta Virus (HDV), Pan-Genotypic [FD3A7] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-Hepatitis Delta Virus (HDV), Pan-Genotypic [FD3A7] Antibody")
This mouse monoclonal Anti-Hepatitis Delta Virus (HDV) antibody was raised against Hepatitis Delta Antigen (HDAg). The two antibody clones, FD3A7 & FD5C4, were screened to ensure pan-genotypic specificity.
Highlights:
- Specifically detect HDAg of all 8 viral genotypes
- Validated in ELISA, western blot, immunofluorescence and in a competitive diagnostic ELISA using serum of HDV-infected patients
Chronic Hepatitis Delta Virus (HDV) infections represent the most severe form of viral hepatitis with about 20 million infected individuals worldwide. HDV is a satellite virus of Hepatitis B Virus (HBV), which means that all patients chronically infected with HDV are always co-infected with HBV. There are 8 different HDV genotypes described worldwide. The HDV genome encodes for only one protein: the Hepatitis Delta Antigen (HDAg).
From the laboratory of Stephan Urban, PhD , Heidelberg University.
This mouse monoclonal Anti-Hepatitis Delta Virus (HDV) antibody was raised against Hepatitis Delta Antigen (HDAg). The two antibody clones, FD3A7 & FD5C4, were screened to ensure pan-genotypic specificity.
Highlights:
- Specifically detect HDAg of all 8 viral genotypes
- Validated in ELISA, western blot, immunofluorescence and in a competitive diagnostic ELISA using serum of HDV-infected patients
Chronic Hepatitis Delta Virus (HDV) infections represent the most severe form of viral hepatitis with about 20 million infected individuals worldwide. HDV is a satellite virus of Hepatitis B Virus (HBV), which means that all patients chronically infected with HDV are always co-infected with HBV. There are 8 different HDV genotypes described worldwide. The HDV genome encodes for only one protein: the Hepatitis Delta Antigen (HDAg).
From the laboratory of Stephan Urban, PhD , Heidelberg University.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Hepatitis Delta Virus (HDV), Pan-Genotypic [FD3A7] Antibody |
| Accession ID: | Synthetic, chimeric sequence (consensus of all 8 genotypes). Most similarity (93%) with Genbank SCC98289 |
| Antigen: | Hepatitis Delta Antigen (HDAg) |
| Molecular Weight: | 25kD |
| Isotype: | IgG1 kappa (FD3A7) and IgG2b kappa (FD5C4) |
| Clonality: | Monoclonal |
| Clone Name: | FD3A7 and FD5C4 |
| Reactivity: | Virus (Hepatitis Delta Virus) |
| Immunogen: | Full-length protein |
| Species Immunized: | Mouse, BALB/c |
| Buffer: | Cell culture supernatant |
| Tested Applications: | WB, IF 1:100 (may be optimized further if needed) |
| Storage: | -80C (Avoid multiple freeze/thaw cycles) |
| Shipped: | Cold Packs |
(A) Western blot. Lysates of cells expressing HDAg of different genotypes was separated by SDSPAGE, blotted and incubated with the mAb FD3A7 at 1:500 dilution. (B) Immunofluorescence. HuH7 cells were transfected with plasmids encoding HDAg of different HDV genotypes. Cells were fixed, permeabilized and incubated with the two mAb clones at 1:20-500 dilution. A goatanti-mouse-Alexa545 antibody was used for detection. Both mAb clones detect HDAg of all HDV genotypes.
- Wang W, Lempp FA, Schlund F, Walter L, Decker CC, Zhang Z, Ni Y, Urban S. Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates. J Hepatol. 2021 Aug;75(2):311-323. doi: 10.1016/j.jhep.2021.03.025. Epub 2021 May 5. PMID: 33845061.
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