HDAC Photoreactive Inhibitor; V-91
V-91 is an azole-based compound which acts as a photoreactive histone deacetylase (HDAC) inhibitor suitable for photoaffinity labeling experiments. This allows for the identification of drug target proteins of biologically active compounds and mapping their binding sites.
Selectivity of V-91 for the active site of HDAC8 was demonstrated by blocking it with SAHA.
From the laboratory of Pavel A. Petukhov, PhD, University of Illinois at Chicago.
Part of The Investigator's Annexe program.
V-91 is an azole-based compound which acts as a photoreactive histone deacetylase (HDAC) inhibitor suitable for photoaffinity labeling experiments. This allows for the identification of drug target proteins of biologically active compounds and mapping their binding sites.
Selectivity of V-91 for the active site of HDAC8 was demonstrated by blocking it with SAHA.
From the laboratory of Pavel A. Petukhov, PhD, University of Illinois at Chicago.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Small Molecule |
| Name: | V-91 |
| Chemical Formula: | C22H26N8O4 |
| Molecular Weight: | 466.5 |
| Format: | solid |
| Purity: | >95%, HPLC |
| Stability: | > 6 months at -20C |
| Comments: | Photoreactive group: arylazide; Activation wavelength: 280nm; Activation period: 3min |
| Storage: | Store at -20C |
| Shipped: | Cold Pack |
Provider
From the laboratory of Pavel A. Petukhov, PhD, University of Illinois at Chicago.
Comments
| Compound | HDAC8 IC50 ± SD (nM) |
| SAHA | 440 ± 2.1 |
| V-91 | 734 ± 22 |
Adapted from Table 1; He, B., et al. Journal of Medicinal Chemistry, 52(22): 7003 - 7013. 2009.
References
- He, B., et al. Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the BindingPoses of HDAC8 Inhibitors.Journal of Medicinal Chemistry. 52(22): 7003 - 7013. 2009.
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