Complement C1s Enzyme
Complement C1s enzyme expressed in E. Coli.
C1s proenzyme is activated when the C1 complex binds to and is activated by antibodies bound to antigens (immune complexes) yielding C1r enzyme, the first protease that initiates the cascade. C1r enzyme in the C1 complex activates C1s proenzyme generating C1s enzyme. The activated C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components. This facilitates the formation of the classical pathway C3 convertase (C4bC2a).
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
Complement C1s enzyme expressed in E. Coli.
C1s proenzyme is activated when the C1 complex binds to and is activated by antibodies bound to antigens (immune complexes) yielding C1r enzyme, the first protease that initiates the cascade. C1r enzyme in the C1 complex activates C1s proenzyme generating C1s enzyme. The activated C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components. This facilitates the formation of the classical pathway C3 convertase (C4bC2a).
From the laboratory of Lakshmi C. Wijeyewickrema, PhD, La Trobe University.
| Product Type: | Protein |
| Name: | C1sCCP12SP |
| Accession ID: | P09871 |
| Source: | Escherichia coli |
| Molecular Weight: | 45156.23 (Predicted), around 18kDa and 29kDa on SDS-PAGE under reducing condition |
| Amino Acid Sequence: | K281-D688 |
| Purity: | >95%, by SDS-PAGE under reducing conditions and visualized by Coomassie Blue Stain |
| Storage: | -80C |
| Shipped: | Dry Ice |
- Duncan RC, Mohlin F, Taleski D, Coetzer TH, Huntington JA, Payne RJ, Blom AM, Pike RN, Wijeyewickrema LC. Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol. 2012 Sep 1;189(5):2365-73.
If you publish research with this product, please let us know so we can cite your paper.
