Anti-Marek's Disease Virus, Serotype 1 [2BN90] Antibody

This IgG1k monoclonal antibody recognizes serotype 1 Marek's disease virus (MDV).

Highlights:

  • Reacts with MDV - Reactive with all serotype 1 isolates, including CV1988
  • Can be useful as a type-specific antibody of choice for serotyping MDV serotype 1 strains and as a probe for studying the role of pp40 in MDV infection and transformation
  • Suitable for ELISA and Immunofluorescence applications

Marek's disease is a highly contagious viral neoplastic disease in chickens. Marek's disease is caused by an alphaherpesvirus known as 'Marek's disease virus' (MDV) or Gallid herpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes.

From the laboratory at United States Department of Agriculture/USDA.

Catalog Number Product Size AVAILABILITY Price Qty
ECD006-FP
Anti-Marek's Disease Virus, Serotype 1 [2BN90] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00

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Specifications
Product Type: Antibody
Antigen: MDV 5
Isotype: IgG1k
Clonality: Monoclonal
Reactivity: Serotype 1
Epitope: pp40
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Storage: -20C
Shipped: Cold Packs
Research
A monoclonal antibody (MAb), 2BN90, was characterized on a panel of Marek's disease virus (MDV) isolates representing three antigenically related serotypes and lymphoblastoid cell lines established from Marek's disease (MD) tumors. It was reactive with all serotype 1 isolates, including CV1988, in both enzyme-linked immunosorbent assay (ELISA) and immunofluorescence (IF) test. The MAb immunoprecipitated and immunoblotted a 40-kilodalton protein, which was found to be phosphorylated by metabolic labeling with 32P inorganic phosphate, and localized to the cell nucleus using the IF test. It reacted with MDV-transformed lymphoblastoid cell lines, and the percentage of reactive cells was enhanced after treatment with iododeoxyuridine. MAb 2BN90 may be useful as a type-specific antibody of choice for serotyping MDV serotype 1 strains and as a probe for studying the role of pp40 in MDV infection and transformation.
Provider
References
  1. Witter RL, Silva RF, Lee LF. New serotype 2 and attenuated serotype 1 Marek's disease vaccine viruses: selected biological and molecular characteristics. Avian Dis. 1987 Oct-Dec;31(4):829-40. PubMed PMID: 2831870.
  2. Lee, L.F. Characterization of a Monoclonal Antibody against a Nuclear Antigen Associated with Serotype-1 Marek's Disease Virus-Infected and Transformed Cells. Avian Diseases Vol. 37, No. 2 (Apr. - Jun., 1993), pp. 561-567. DOI: 10.2307/1591687

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