Anti-Marek's Disease Virus, Serotype 1 [2BN90] Antibody
![Anti-Mareks Disease Virus, Serotype 1 [2BN90] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1812_2001202001270218110.jpg "Anti-Mareks Disease Virus, Serotype 1 [2BN90] Antibody")
This IgG1k monoclonal antibody recognizes serotype 1 Marek's disease virus (MDV).
Highlights:
- Reacts with MDV - Reactive with all serotype 1 isolates, including CV1988
- Can be useful as a type-specific antibody of choice for serotyping MDV serotype 1 strains and as a probe for studying the role of pp40 in MDV infection and transformation
- Suitable for ELISA and Immunofluorescence applications
Marek's disease is a highly contagious viral neoplastic disease in chickens. Marek's disease is caused by an alphaherpesvirus known as 'Marek's disease virus' (MDV) or Gallid herpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes.
From the laboratory at United States Department of Agriculture/USDA.
This IgG1k monoclonal antibody recognizes serotype 1 Marek's disease virus (MDV).
Highlights:
- Reacts with MDV - Reactive with all serotype 1 isolates, including CV1988
- Can be useful as a type-specific antibody of choice for serotyping MDV serotype 1 strains and as a probe for studying the role of pp40 in MDV infection and transformation
- Suitable for ELISA and Immunofluorescence applications
Marek's disease is a highly contagious viral neoplastic disease in chickens. Marek's disease is caused by an alphaherpesvirus known as 'Marek's disease virus' (MDV) or Gallid herpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes.
From the laboratory at United States Department of Agriculture/USDA.
Specifications
| Product Type: | Antibody |
| Antigen: | MDV 5 |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Reactivity: | Serotype 1 |
| Epitope: | pp40 |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Storage: | -20C |
| Shipped: | Cold Packs |
Research
A monoclonal antibody (MAb), 2BN90, was characterized on a panel of Marek's disease virus (MDV) isolates representing three antigenically related serotypes and lymphoblastoid cell lines established from Marek's disease (MD) tumors. It was reactive with all serotype 1 isolates, including CV1988, in both enzyme-linked immunosorbent assay (ELISA) and immunofluorescence (IF) test. The MAb immunoprecipitated and immunoblotted a 40-kilodalton protein, which was found to be phosphorylated by metabolic labeling with 32P inorganic phosphate, and localized to the cell nucleus using the IF test. It reacted with MDV-transformed lymphoblastoid cell lines, and the percentage of reactive cells was enhanced after treatment with iododeoxyuridine. MAb 2BN90 may be useful as a type-specific antibody of choice for serotyping MDV serotype 1 strains and as a probe for studying the role of pp40 in MDV infection and transformation.
Provider
From the laboratory at United States Department of Agriculture/USDA.
References
- Witter RL, Silva RF, Lee LF. New serotype 2 and attenuated serotype 1 Marek's disease vaccine viruses: selected biological and molecular characteristics. Avian Dis. 1987 Oct-Dec;31(4):829-40. PubMed PMID: 2831870.
- Lee, L.F. Characterization of a Monoclonal Antibody against a Nuclear Antigen Associated with Serotype-1 Marek's Disease Virus-Infected and Transformed Cells. Avian Diseases Vol. 37, No. 2 (Apr. - Jun., 1993), pp. 561-567. DOI: 10.2307/1591687
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