Anti-Human/Murine Chimeric Flavivirus (6B6C-1) Antibodies

These mouse antibodies incorporate the variable regions of broadly flavivirus cross-reactive mAb 6B6C-1 (specific for the flaviviral envelope (E) protein) into a plasmid construct containing the human IgG γ1 chain. The antibodies recognize Flavivirus (6B6C-1).

Highlights:

  • 6ME2: Reacts with the E protein of the West Nile Virus (WNV)-VLP (virus like particles),  Yellow Fever Virus (YFV) and Saint Louis Encephalitis Virus (SLEV) seed antigens in MAC-ELISA,  Suckling Mouse Brain (SMB) and VLP antigens in MAC-ELISA
  • 6GF4: Reacts with YFV, WNV and Japanese encephalitis virus (JEV); Acheives positive P/N values with each flaviviral antigen tested in the indirect IgG ELISA
  • Suitable for Western Blot and ELISA applications

The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.

From the laboratory of Centers for Disease Control and Prevention.

Catalog Number Product Size AVAILABILITY Price Qty
ECD007-FP
Anti-Human/Murine Chimeric Flavivirus (6B6C-1) [6GF4] Antibody, 5mL (supernatant)
5mL (supernatant) 3-5 weeks
Price: $250.00
ECD008-FP
Anti-Human/Murine Chimeric Flavivirus (6B6C-1) [6ME2] Antibody, 5mL (supernatant)
5mL (supernatant) 3-5 weeks
Price: $250.00

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Specifications
Product Type: Antibody
Antigen: Flaviviral envelope (E) protein
Isotype: 6GF4: IgG1
6ME2: IgM
Clonality: Monoclonal
Clone Name: 6GF4
6ME2
Immunogen: 6GF4: pdHL2-6G, VH and VK regions of mMAb 6B6C-1 was incorporated separately into the human IgG expression construct pdHL2 generating plasmid pdHL2-6G (6B6C-1:IgG)
6ME2: The VH and VK regions of 6B6C-1 were incorporated into the human IgM expression construct pJH2 by ligation, generating plasmid pJH-6M (6B6C-1:IgM)
Species Immunized: None; Sp2/0-Ag14 (Sp2) murine myeloma cells
Buffer: Cell Culture Supernatant
Storage: -80C
Shipped: Dry Ice
Provider
 
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