CEACAM1/CD66a Antibodies
These mouse IgG1 kappa monoclonal antibodies were raised against recombinant glycoprotein and are specific for human Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1).
Highlights:
- React with human CEACAM1
- Clone B3-17 is suitable for functional assay, Flow Cytometry, FACS, and ELISA applications
- Clone C5-1X/8 is suitable for Western Blot, Immunoprecipitation, IHC-fr, IHC-p, and Immunoflorescence applications
CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) is thought to be a member of the immunoglobulin superfamily and is known as an epithelial tumor suppressor and an angiogenic growth factor. It has also been linked to the actin-based cytoskeleton. In T and B cells CEACAM1 mediates co-stimulatory functions. CEACAM1 is also known as a cellular receptor for a number of human pathogenic bacteria including Neisseria, Moraxella and Helicobacter pylori. The loss of activity of CEACAM1 has been related to the development of colorectal cancer. CEACAM1 is also expressed in distinct vessel and lymph endothelial cells.
From the laboratory of Bernhard B. Singer, PhD, University of Duisburg-Essen.
These mouse IgG1 kappa monoclonal antibodies were raised against recombinant glycoprotein and are specific for human Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1).
Highlights:
- React with human CEACAM1
- Clone B3-17 is suitable for functional assay, Flow Cytometry, FACS, and ELISA applications
- Clone C5-1X/8 is suitable for Western Blot, Immunoprecipitation, IHC-fr, IHC-p, and Immunoflorescence applications
CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) is thought to be a member of the immunoglobulin superfamily and is known as an epithelial tumor suppressor and an angiogenic growth factor. It has also been linked to the actin-based cytoskeleton. In T and B cells CEACAM1 mediates co-stimulatory functions. CEACAM1 is also known as a cellular receptor for a number of human pathogenic bacteria including Neisseria, Moraxella and Helicobacter pylori. The loss of activity of CEACAM1 has been related to the development of colorectal cancer. CEACAM1 is also expressed in distinct vessel and lymph endothelial cells.
From the laboratory of Bernhard B. Singer, PhD, University of Duisburg-Essen.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Hek293 produced recombinant human CEACAMl-Fc |
| Accession ID: | P13688 |
| Molecular Weight: | 120 kDa |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Clone Name: | B3-17, C5-1X8 |
| Specificity: | Antibodies do not react with CEACAMs of other species (namely mouse, rat, cow, dog maccaca, rabbit) |
| Reactivity: | Human |
| Immunogen: | Recombinant glycoprotein |
| Species Immunized: | Mouse |
| Epitope: | Does not bind to the N domain of human CEACAM1 |
| Purification Method: | Protein G |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: |
B3-17: functional assay, Flow Cytometry, FACS, and ELISA C5-1X/8: Western Blot, Immunoprecipitation, IHC-fr, IHC-p, and Immunoflorescence |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Singer BB, et al. (2014) Soluble CEACAM8 interacts with CEACAMl inhibiting TLR2-triggered immune responses.
- PLoS ONE9(4):e94106 Seifert et al. (2015) Functional capacities of human lgM memory B cells in early inflammatory responses andvsecondary germinal center reactions. Proceedings of the National Academy of Sciences 112(6):546-555.
- Ullrich et al. (2015) CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival. Cancer Res. May 1;75(9):1897-907.
- Khairnar et al. (2015) CEACAMl induces B-ce!I survival and is essential for protective antiviral antibody production. Nat Commun. 18;6:6217.
- Javaheri et al. (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2:16189.
- Mach et al. (2017) Soluble CEACAMl and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy. Am J Reprod lmmunol. 2017 Oct;78(4). doi: 10.1111/aji.12700.
- Khairnar et al. (2018} CEACAM 1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 9(1):2561.
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