CEACAM1/CD66a Antibodies

These mouse IgG1 kappa monoclonal antibodies were raised against recombinant glycoprotein and are specific for human Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1).

Highlights:

  • React with human CEACAM1
  • Clone B3-17 is suitable for functional assay, Flow Cytometry, FACS, and ELISA applications
  • Clone C5-1X/8 is suitable for Western Blot, Immunoprecipitation, IHC-fr, IHC-p, and Immunoflorescence applications

CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) is thought to be a member of the immunoglobulin superfamily and is known as an epithelial tumor suppressor and an angiogenic growth factor. It has also been linked to the actin-based cytoskeleton. In T and B cells CEACAM1 mediates co-stimulatory functions. CEACAM1 is also known as a cellular receptor for a number of human pathogenic bacteria including Neisseria, Moraxella and Helicobacter pylori. The loss of activity of CEACAM1 has been related to the development of colorectal cancer. CEACAM1 is also expressed in distinct vessel and lymph endothelial cells.

From the laboratory of Bernhard B. Singer, PhD, University of Duisburg-Essen.

Catalog Number Product Size AVAILABILITY Price Qty
EDE003
Anti-CEACAM1/CD66a [B3-17] Antibody, 100ug
100ug In stock
Price: $299.00
EDE004
Anti-CEACAM1/CD66a [C5-1X/8] Antibody, 100ug
100ug In stock
Price: $299.00
Specifications
Product Type: Antibody
Accession ID: NM_ 001712.4
Antigen: Hek293 produced recombinant human CEACAMl-Fc
Molecular Weight: 120 kDa
Isotype: IgG1k
Clonality: Monoclonal
Clone Name: B3-17, C5-1X8
Specificity: Antibodies do not react with CEACAMs of other species (namely mouse, rat, cow, dog maccaca, rabbit)
Reactivity: Human
Immunogen: Recombinant glycoprotein
Species Immunized: Mouse
Epitope: Does not bind to the N domain of human CEACAM1
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: B3-17: functional assay, Flow Cytometry, FACS, and ELISA
C5-1X/8: Western Blot, Immunoprecipitation, IHC-fr, IHC-p, and Immunoflorescence
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Bernhard B. Singer, PhD, University of Duisburg-Essen.

References
  1. Singer BB, et al. (2014) Soluble CEACAM8 interacts with CEACAMl inhibiting TLR2-triggered immune responses.
  2. PLoS ONE9(4):e94106 Seifert et al. (2015) Functional capacities of human lgM memory B cells in early inflammatory responses andvsecondary germinal center reactions. Proceedings of the National Academy of Sciences 112(6):546-555.
  3. Ullrich et al. (2015) CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival. Cancer Res. May 1;75(9):1897-907.
  4. Khairnar et al. (2015) CEACAMl induces B-ce!I survival and is essential for protective antiviral antibody production. Nat Commun. 18;6:6217.
  5. Javaheri et al. (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2:16189.
  6. Mach et al. (2017) Soluble CEACAMl and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy. Am J Reprod lmmunol. 2017 Oct;78(4). doi: 10.1111/aji.12700.
  7. Khairnar et al. (2018} CEACAM 1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 9(1):2561.

If you publish research with this product, please let us know so we can cite your paper.

 
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