Cyclic Diguanosine Monophosphate (c-di-GMP)

Cyclic diguanosine monophosphate (c-di-GMP) produced from Agrobacterium vitis protein engineered Diguanylate Cyclase over-expressed in Escherichia coli.

Highlights:

  • Highly pure - >98% by HPLC

Cyclic-di-GMP is a second messenger used in signal transduction in bacteria, important in studies of bacterial virulence, bacterial infectiousness, pathogenesis, vaccine adjuvants (potentially in MRSA vaccines), innate immunity response, bacterial biofilm formation, bacterial cell-cell interactions, and bacterial cell adhesion. Biological activity regulated by cyclic-di-GMP is mediated through binding to many different receptors. Additionally, it has been more recently shown that cyclic-di-GMP induces the production of type I interferons in a STING or DDX41 dependent manner in the mammalian innate immune system.

From the laboratory of Elizabeth M. Boon, PhD, Stony Brook University.

Catalog Number Product Size AVAILABILITY Price Qty
ESB013
Cyclic Diguanosine Monophosphate (c-di-GMP), 2mg
2mg In stock
Price: $250.00
Specifications
Product Type: Small Molecule
Name: Cyclic Diguanosine Monophosphate (c-di-GMP)
Alternative Name(s): Cyclic diguanylate, 3',5'-Cyclic diguanylic acid, c-di-GMP, cyclic di-GMP
Chemical Formula: C20H24N10O142
CAS number: 61093-23-0
Molecular Weight: 690.09 g/mol
Format: White Powder
Purity: >98%, HPLC
Solubility: Water
Spectral Information: Absorbance 260
Storage: -20C
Shipped: Dry ice
Provider
From the laboratory of Elizabeth M. Boon, PhD, Stony Brook University.
References
  1. Nesbitt NM, Arora DP, Johnson RA, Boon EM. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst). 2015 May 5;7:30-37.

If you publish research with this product, please let us know so we can cite your paper.

 
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