Cyclic Diguanosine Monophosphate (c-di-GMP)
Cyclic diguanosine monophosphate (c-di-GMP) produced from Agrobacterium vitis protein engineered Diguanylate Cyclase over-expressed in Escherichia coli.
Highlights:
- Highly pure - >98% by HPLC
Cyclic-di-GMP is a second messenger used in signal transduction in bacteria, important in studies of bacterial virulence, bacterial infectiousness, pathogenesis, vaccine adjuvants (potentially in MRSA vaccines), innate immunity response, bacterial biofilm formation, bacterial cell-cell interactions, and bacterial cell adhesion. Biological activity regulated by cyclic-di-GMP is mediated through binding to many different receptors. Additionally, it has been more recently shown that cyclic-di-GMP induces the production of type I interferons in a STING or DDX41 dependent manner in the mammalian innate immune system.
From the laboratory of Elizabeth M. Boon, PhD, Stony Brook University.
Cyclic diguanosine monophosphate (c-di-GMP) produced from Agrobacterium vitis protein engineered Diguanylate Cyclase over-expressed in Escherichia coli.
Highlights:
- Highly pure - >98% by HPLC
Cyclic-di-GMP is a second messenger used in signal transduction in bacteria, important in studies of bacterial virulence, bacterial infectiousness, pathogenesis, vaccine adjuvants (potentially in MRSA vaccines), innate immunity response, bacterial biofilm formation, bacterial cell-cell interactions, and bacterial cell adhesion. Biological activity regulated by cyclic-di-GMP is mediated through binding to many different receptors. Additionally, it has been more recently shown that cyclic-di-GMP induces the production of type I interferons in a STING or DDX41 dependent manner in the mammalian innate immune system.
From the laboratory of Elizabeth M. Boon, PhD, Stony Brook University.
| Product Type: | Small Molecule |
| Name: | Cyclic Diguanosine Monophosphate (c-di-GMP) |
| Alternative Name(s): | Cyclic diguanylate, 3',5'-Cyclic diguanylic acid, c-di-GMP, cyclic di-GMP |
| CAS number: | 61093-23-0 |
| Chemical Formula: | C20H24N10O142 |
| Molecular Weight: | 690.09 g/mol |
| Format: | White Powder |
| Purity: | >98%, HPLC |
| Solubility: | Water |
| Spectral Information: | Absorbance 260 |
| Storage: | -20C |
| Shipped: | Dry ice |
- Nesbitt NM, Arora DP, Johnson RA, Boon EM. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst). 2015 May 5;7:30-37.
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