Anti-Chikungunya virus (CHIKV) Antibodies
These mouse IgG2 monoclonal antibodies were raised against live Chikungunya virus (CHIKV) and recognize Chikungunya virus.
Highlights:
- Reacts with Chikungunya virus (CHIKV)
- Suitable for Western Blot and Immunofluorscence applications
Chikungunya virus (CHIKV) is known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4-7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhea, vomiting and rash. Myalgia and chronic, incapitating polyarthralgia is nevertheless the defining symptom of the disease, often persisting for weeks, months or even years. CHIKV gained its infamity from the severe outbreak in the Indian Ocean island of La Re'union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced hemorrhagic fever manifestations. Unprecedentedly high fatality rates of one death per 1,000 infections were reported, along with atypical clinical manifestations such as severe dermatological lesions, lymphopenia, lethal hepatitis and encephalitis in predominantly susceptible individuals. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa. Mouse monoclonal antibodies that are specific to chikungunya virus can be used as a research or diagnostic reagent to detect infection of cells.
From the laboratory of A*STAR Institute of Molecular and Cell Biology (IMCB) Monoclonal Antibody Unit.
These mouse IgG2 monoclonal antibodies were raised against live Chikungunya virus (CHIKV) and recognize Chikungunya virus.
Highlights:
- Reacts with Chikungunya virus (CHIKV)
- Suitable for Western Blot and Immunofluorscence applications
Chikungunya virus (CHIKV) is known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4-7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhea, vomiting and rash. Myalgia and chronic, incapitating polyarthralgia is nevertheless the defining symptom of the disease, often persisting for weeks, months or even years. CHIKV gained its infamity from the severe outbreak in the Indian Ocean island of La Re'union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced hemorrhagic fever manifestations. Unprecedentedly high fatality rates of one death per 1,000 infections were reported, along with atypical clinical manifestations such as severe dermatological lesions, lymphopenia, lethal hepatitis and encephalitis in predominantly susceptible individuals. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa. Mouse monoclonal antibodies that are specific to chikungunya virus can be used as a research or diagnostic reagent to detect infection of cells.
From the laboratory of A*STAR Institute of Molecular and Cell Biology (IMCB) Monoclonal Antibody Unit.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Chikungunya virus (CHIKV) |
| Isotype: |
11E7: IgG2a 6A11: IgG2b |
| Clonality: | Monoclonal |
| Clone Name: |
11E7 6A11 |
| Reactivity: | Chikungunya virus |
| Immunogen: | Live Chikungunya virus |
| Species Immunized: | Mouse |
| Buffer: | Cell culture supernatant |
| Tested Applications: | WB, IF |
| Storage: | 80C |
| Shipped: | Cold Packs |
Western Blot and Immunofluorescence
Figure (A) and (C): Western Blot analysis performed using cells infected with CHIKV (Inf) or mock infected (Mock). The 47kDa protein detected in the infected cells only is likely to be the E1 protein of CHIKV. MAb 11E7 was used for (A) and mAb 6A11 was used for (C). Figure (B) and (D): Immunostaining of cells infected with CHIKV (Inf) or mock infected (Mock) at 24 hours post-infection (hpi). MAb 11E7 was used for (B) and mAb 6A11 wasused for (D).
From the laboratory of A*STAR Institute of Molecular and Cell Biology (IMCB) Monoclonal Antibody Unit.
If you publish research with this product, please let us know so we can cite your paper.
