Anti-nitrated Amyloid Beta, Tyr10 [3-NTyr10-Ab] Antibody

This rabbit monoclonal antibody was raised against nitrated peptide FRHDSG(3NT-Y)EVHHQ and is specific for human nitrated Tyr10 Amyloid-beta.

Highlights:

  • Reacts with human nitrated Tyr10 Amyloid-beta
  • No cross reactivity to mouse and rat
  • Suitable for Immunohistochemistry, Western Blot and ELISA applications

Part of the inflammatory response in Alzheimer's disease is the upregulation of the inducible nitric oxide synthase NOS2 resulting in increased NO production. NO contributes to cell signaling by inducing posttranslational protein modifications. Under pathological conditions there is a shift to the formation of protein tyrosine nitration by secondary products like peroxynitrite and nitrogen dioxide. Amyloid is nitrated at tyrosine 10 in brains of patients with Alzheimer's disease. Nitration accelerates its aggregation and is present in Amyloid Β plaques.

From the laboratory of Michael T. Heneka, MD, University of Bonn.

Catalog Number Product Size AVAILABILITY Price Qty
EBN004
Anti-nitrated Amyloid Beta, Tyr10 [3-NTyr10-Ab] Antibody, 5mL (supernatant)
5mL 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: Nitrated Tyr10 Amyloid-beta
Clonality: Monoclonal
Clone Name: 3-NTyr10-Ab
Reactivity: Human
Immunogen: Synthetically nitrated peptide FRHDSG(3NT-Y)EVHHQ
Species Immunized: Rabbit
Buffer: Cell Culture Supernatant
Tested Applications: WB (1:500-1000), IHC (1:50-100), ELISA (1:1000)
Storage: 80C
Shipped: Dry Ice
Provider
From the laboratory of Michael T. Heneka, MD, University of Bonn.
References
  1. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng T-C, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PSI mice. Nature 493:674-678.

If you publish research with this product, please let us know so we can cite your paper.

 
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