Anti-GD2 Idiotypic Antibodies

These IgG2 mouse monoclonal idiotypic antibodies were produced against ME361 and are specific for human ganglioside GD2.

Highlights:

  • Idiotypic antibody that functionally mimics GD2
  • Suitable for Immunoprecipitation applications

Anti-idiotypic antibodies are antibodies that can be elicited against the variable region of other antibody molecules. GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. Gangliosides are a class of carbohydrate-rich glycolipids of extremely large size and complexity, which are usually found on the outer surface of cell membranes, especially among the cells of the nervous system. GD2 is present in central nervous tissue, in melanomas, gliomas, neuroblastoma, and small cell lung carcinoma at high density. In general, ganglioside antigen GD2 occurs in primary and metastic melanoma and is less abundantly present in normal tissue.

From the laboratory of Dorothee Herlyn, DVM, The Wistar Institute.

Catalog Number Product Size AVAILABILITY Price Qty
EWI039
Anti-GD2 Idiotypic [TA17A C12] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
EWI040
Anti-GD2 Idiotypic [TA412G C11] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
EWI041
Anti-GD2 Idiotypic [TB310B C11] Antibody, 100ug
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: Anti-idiotypic, mimic GD2 function
Isotype: IgG2a, IgG2b
Clonality: Monoclonal
Clone Name: TA17A C12
TA412G C11
TB310B C11
Reactivity: Human
Immunogen: ME361
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: IP
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratory of Dorothee Herlyn, DVM, The Wistar Institute.

References
  1. Basak S, Birebent B, Purev E, Somasundaram R, Maruyama H, Zaloudik J, Swoboda R, Strittmatter W, Li W, Luckenbach A, Song H, Li J, Sproesser K, Guerry D, Nair S, Furukawa K, Herlyn D. Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside. Cancer Immunol Immunother. 2003 Mar;52(3):145-54. Epub 2003 Feb 11. PubMed PMID: 12649743.

If you publish research with this product, please let us know so we can cite your paper.

 
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