Anti-TIAM1 [4E7b] Antibody

This mouse monoclonal antibody was raised against recombinant T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and recognizes human, mouse and rat TIAM1.

Highlights:

  • Reacts with human, mouse and rat TIAM1
  • Suitable for Western Blot and Immunoprecipitation applications

T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome.

From the laboratories of The Antibody Technology Resource and Jihong Bai, PhD, Fred Hutchinson Cancer Research Center.

Catalog Number Product Size AVAILABILITY Price Qty
EFH006
Anti-TIAM1 [4E7b] Antibody
100ug 3-5 weeks
Price: $299.00
Specifications
Product Type: Antibody
Antigen: TIAM1
Accession ID: NP_001002255.1
Molecular Weight: 178 kDa
Clonality: Monoclonal
Clone Name: 4E7b
Reactivity: Human, Mouse and Rat
Immunogen: Recombinant TIAM1 GEF domain (mouse 1029-1418)
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: WB (1:1000), IP
Storage: -20C
Shipped: Cold Packs
Provider
From the laboratories of The Antibody Technology Resource and Jihong Bai, PhD, Fred Hutchinson Cancer Research Center.
References
  1. Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell. 2018 Jun 18;45(6):738-752.e6. doi: 10.1016/j.devcel.2018.05.021. PubMed PMID: 29920278.

If you publish research with this product, please let us know so we can cite your paper.

 
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