Anti-ADAR2 (ADARB1) [1.3.1] Antibody
![Anti-ADAR2 (ADARB1) [1.3.1] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1672_2001202001265716710.jpg "Anti-ADAR2 (ADARB1) [1.3.1] Antibody")
This mouse IgG monoclonal antibody was raised against purified GST-double-stranded RNA-specific editase 1 (ADAR2a) fusion protein (N-terminal Region, Amino Acids 2-179) and recognizes human and mouse ADAR2.
Highlights:
- Reacts with human and mouse ADAR2
- Does not cross-react with different members of the ADAR family
- Suitable for Western Blot, Immunohistochemistry and Immunostaining applications
ADAR2 or ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
This mouse IgG monoclonal antibody was raised against purified GST-double-stranded RNA-specific editase 1 (ADAR2a) fusion protein (N-terminal Region, Amino Acids 2-179) and recognizes human and mouse ADAR2.
Highlights:
- Reacts with human and mouse ADAR2
- Does not cross-react with different members of the ADAR family
- Suitable for Western Blot, Immunohistochemistry and Immunostaining applications
ADAR2 or ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
| Product Type: | Antibody |
| Antigen: | ADAR2 (ADARB1; adenosine deaminase, RNA specific B1) |
| Accession ID: | P78563 |
| Molecular Weight: | 90 kDa |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | 1.3.1 |
| Specificity: | Native and Recombinant ADAR2; does not cross-react with different members of the ADAR family |
| Reactivity: | Human and mouse |
| Immunogen: | N-terminal, raised Against Purified GST-ADAR2a Fusion Protein (N-terminal Region, Amino Acids 2-179) |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, IHC, Immunostaining |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem. 2003 May 9;278(19):17093-102. Epub 2003 Mar 4. PubMed PMID: 12618436.
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