Anti-PD-1 [J110] Antibody
![Anti-PD-1 [J110] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1404_2001202001264614030.jpg "Anti-PD-1 [J110] Antibody")
This mouse IgG1 monoclonal antibody was generated against native programmed cell death protein 1 (PD-1) or cluster of differentiation 29 (C279) and is specific for PD-1.
Highlights:
- Recognizes PD-1
- Suitable for ELISA, Immunohistochemistry and Western Blot applications
PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2.
PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).
This mouse IgG1 monoclonal antibody was generated against native programmed cell death protein 1 (PD-1) or cluster of differentiation 29 (C279) and is specific for PD-1.
Highlights:
- Recognizes PD-1
- Suitable for ELISA, Immunohistochemistry and Western Blot applications
PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2. PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).
| Product Type: | Antibody |
| Antigen: | Programmed cell death protein 1 (PD-1) and CD279 (cluster of differentiation 279) |
| Accession ID: | Q15116 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | J110 |
| Immunogen: | Native PD-1 protein |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, pH 7.2 |
| Tested Applications: | ELISA, WB, IHC, FFPE, IHC |
| Storage: | -20C |
| Shipped: | Cold packs |
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