Anti-Flavivirus Envelope (E) Protein [D1-4G2-4-15] Antibody

This mouse IgG2a monoclonal antibody was generated against flavivirus envelope proteins and recognizes the domain II of protein E (fusion loop) of flavivirus.

Highlights:

  • Recognizes Dengue virus, West Nile Virus, Japanese Encephalitis and Zika virus
  • Suitable for Immunofluorescence applications

The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.

Catalog Number Product Size AVAILABILITY Price Qty
FCG001
Anti-Flavivirus Envelope (E) Protein [D1-4G2-4-15] Antibody, 100ug
100ug In stock
Price: $360.00
Specifications
Product Type: Antibody
Antigen: Flavivirus Envelope (E) Protein
Isotype: IgG2a
Clonality: Monoclonal
Clone Name: D1-4G2-4-15
Reactivity: Virus
Immunogen: Flavivirus envelope proteins
Species Immunized: Mouse
Purification Method: Protein G
Buffer: PBS, pH 7.2
Tested Applications: IF
Storage: -20C
Shipped: Cold packs
Data

Detection of ZIKV via immunofluorescence

Sample confocal images of forebrain-specific hNPCs 56 hr after infection with ZIKV supernatant, immunostained for ZIKV envelop protein (ZIKVE; green) and DAPI (gray). Cells were differentiated from the C1-2 hiPSC line. Scale bars, 20 ?m.

Adapted from: Tang H, et al. Cell Stem Cell. 2016 May 5;18(5):587-90.

References
  1. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H, Ming GL. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016 May 5;18(5):587-90.

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