Anti-VSV-N [10G4] Antibody

This monoclonal antibody reacts with VSV N protein.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The N protein (or nucleocapsid protein) tightly binds viral RNA.  This activity of the N protein protects the viral genome from cellular sensors and nuclease degradation.  Additionally, accumulation of the N protein during VSV replication results in a switch from viral gene transcription to genome replication.

From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.

 

Catalog Number Product Size AVAILABILITY Price Qty
EB0009
Anti-VSV-N [10G4] Antibody, 100 ug
100ug (1mg/mL) In stock
Price: $356.00
Specifications
Product Type: Antibody
Name: anti-VSV-N (10G4)
Host: Mouse
Isotype: IgG2a kappa
Clonality: Monoclonal
Clone Name: 10G4
Specificity: VSV-Ind nucleocapsid (N) protein
Immunogen: VSV infection
Format: Liquid
Purity: Protein G purified
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: Western blot (1:1000)
Concentration: 1mg/mL
Amount: 100uL
Storage: -20C (avoid repeated freeze / thaw cycles)
Shipped: Cold packs
Provider
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
References
  1. Lyles DS, Puddington L, McCreedy BJ Jr. Vesicular stomatitis virus M protein in the nuclei of infected cells. J Virol. 1988 Nov;62(11):4387-92. PubMed PMID: 2845149
  2. Lefrancios L, Lyles DS. The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies. Virology 121: 157-167, 1982.
  3. Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015 Mar 30;6:6660. doi: 10.1038/ncomms7660. PubMed PMID: 25818806; PubMed Central PMCID: PMC4380233. View Article
  4. Bresk CA, Hofer T, Wilmschen S, Krismer M, Beierfuß A, Effantin G, Weissenhorn W, Hogan MJ, Jordan APO, Gelman RS, Montefiori DC, Liao HX, Schmitz JE, Haynes BF, von Laer D, Kimpel J. Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector. Viruses. 2019 Feb 15;11(2). pii: E159. View Article

If you publish research with this product, please let us know so we can cite your paper.

 
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