Anti-LNFPIII/Lewis X (CD15) [E.5] Antibody

This mouse IgM monoclonal antibody was generated against carbohydrate and is specific for human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC).

Highlights:

  • Reacts with human Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC)
  • Originally used in S. mansoni research - Also useful in the research involving nematodes and, possibly trematodes
  • Recommended for Flow Cytometry applications

Lacto-N-fucopentaose III is an oligosaccharide found in human milk and shown to be involved in the development of the mucosal immune system. LNFPIII contains a Lewis X structure in the oligosaccharide. Lewis X also known as CD15 is an immunological significant molecule that can be expressed in glycoproteins, glycolipids and proteoglycans and has diagnostic relevance in many diseases and is a marker for pluripontent stem cells.

From the laboratory of Donald A. Harn, PhD, University of Georgia.

Catalog Number Product Size AVAILABILITY Price Qty
EGA072
Anti-LNFPIII/Lewis X (CD15) [E.5] Antibody (supernatant), 5mL
5mL (supernatant) 2-3 weeks
Price: $269.00
EGA073
Anti-LNFPIII/Lewis X (CD15) [E.5] Hybridoma
1 vial 2-3 weeks
Price: $913.00
Specifications
Product Type: Antibody
Antigen: Lacto-N-fucopentaose III (LNFPIII)/Lewis X or LNFPIII-neoglycoconjugates (NGC)
Isotype: IgM
Clonality: Monoclonal
Clone Name: E.5
Reactivity: Human
Immunogen: Carbohydrate
Species Immunized: Mouse
Buffer: Cell Culture supernatant
Tested Applications: Fluorsecent staining for flow cytometry
Storage: -80C
Shipped: Dry ice
Provider
From the laboratory of Donald A. Harn, PhD, University of Georgia.
References
  1. Srivastava L, Tundup S, Choi BS, Norberg T, Harn D. Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells. Infect Immun. 2014 May;82(5):1891-903.
  2. Atochina O, Harn D. LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction. Clin Diagn Lab Immunol. 2005 Sep;12(9):1041-9.
  3. Tundup S, Srivastava L, Norberg T, Watford W, Harn D. A Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway. PLoS One. 2015 Sep 4;10(9):e0137495.

If you publish research with this product, please let us know so we can cite your paper.

 
Loading...
Loading...