Rabbit Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody

This rabbit polyclonal antibody was generated against E. coli produced fusion protein (pET28c) and recognizes mouse Polycystin-1 (PC1) cytosolic carboxyl terminus (CC) amino acid residues 4123–4291.

Highlights

  • Reacts with mouse PC1
  • Suitable for Western Blot and Immunoprecipitation applications

Polycystin-1 (PC1) is the gene product of PKD1 that is mutated in human autosomal dominant polycystic Kidney disease. It is required for tubular morphogenesis and maintenance of the kidney and other organs. PC1 is a 11-transmembrane glycoprotein that is cic-autoproteolytically cleaved at juxtamembrane extracellular GPS/GAIN in vivo, resulting a N-terminal cleavage fragment and a C-terminal cleavage fragment in the kidney and other tissues.

Also available: Chicken Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody.

From the laboratory of Feng Qian, PhD, The Johns Hopkins University.

Catalog Number Product Size AVAILABILITY Price Qty
EJH002
Rabbit Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody, 100uL
100uL In stock
Price: $321.00
Specifications
Product Type: Antibody
Antigen: Mouse PC1 cytosolic carboxyl terminus (CC)
Accession ID: NP_038658
Molecular Weight: 18 kDa
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: E. coliproduced fusion protein (pET28c)
Species Immunized: Rabbit
Epitope: Amino acid residues 4123?4291
Buffer: Serum
Tested Applications: WB (1:1-2000)
Storage: -80C
Shipped: Dry ice
Provider
From the laboratory of Feng Qian, PhD, The Johns Hopkins University.
References
  1. Yu S, Hackmann K, Gao J, He X, Piontek K, García-González MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93.

If you publish research with this product, please let us know so we can cite your paper.

 
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