Chicken Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody

This chicken IgY polyclonal antibody was generated against E. coli produced fusion protein (pET28c) and recognizes mouse Polycystin-1 (PC1) cytosolic carboxyl terminus (CC) amino acid residues 4123–4291.

Highlights

  • Reacts with mouse PC1
  • Suitable for Immunoprecipitation applications

Polycystin-1 (PC1) is the gene product of PKD1 that is mutated in human autosomal dominant polycystic Kidney disease. It is required for tubular morphogenesis and maintenance of the kidney and other organs. PC1 is a 11-transmembrane glycoprotein that is cic-autoproteolytically cleaved at juxtamembrane extracellular GPS/GAIN in vivo, resulting a N-terminal cleavage fragment and a C-terminal cleavage fragment in the kidney and other tissues.

Also available: Rabbit Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody.

From the laboratory of Feng Qian, PhD, The Johns Hopkins University.

Catalog Number Product Size AVAILABILITY Price Qty
EJH001
Chicken Anti-Mouse Polycystin-1 (PC1), C-Terminal Antibody, 100uL
100uL In stock
Price: $321.00
Specifications
Product Type: Antibody
Antigen: Mouse PC1 cytosolic carboxyl terminus (CC)
Accession ID: NP_038658
Molecular Weight: 18 kDa
Isotype: IgY
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: E. coliproduced fusion protein (pET28c)
Species Immunized: Chicken
Epitope: Amino acid residues 4123?4291
Purification Method: EGGstract IgY Purification System
Tested Applications: While titration is recommended for each tissues for optimization, we suggest to use 2-5 microliter of chicken CC for IP ( for 1 ml protein sample, 1-5 mg/ml)
Storage: -80C
Shipped: Dry ice
Provider
From the laboratory of Feng Qian, PhD, The Johns Hopkins University.
References
  1. Yu S, Hackmann K, Gao J, He X, Piontek K, García-González MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93.

If you publish research with this product, please let us know so we can cite your paper.

 
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