Anti-phospho TIF1-beta (KAP1), Ser824 Antibody
This rabbit IgG polyclonal antibody was generated against a transcription intermediary factor 1-beta (TIF1-beta, KAP1) phospho-peptide and recognizes human KAP1 phosphorylated at Ser824.
Highlights:
- Specific for human KAP1 phosphorylated at Ser824
- Recommended for Western Blot applications
KAP1 is a nuclear corepressor for KRAB domain-containing zinc finger proteins. KAP1 recruits CHD3 and through this mediates gene silencing. KAP1 increases H3K9 methylation and disposes HP1 proteins to silence gene expression. Recruitment of SETDB1 by KAP1 induces heterochromatinization.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
This rabbit IgG polyclonal antibody was generated against a transcription intermediary factor 1-beta (TIF1-beta, KAP1) phospho-peptide and recognizes human KAP1 phosphorylated at Ser824.
Highlights:
- Specific for human KAP1 phosphorylated at Ser824
- Recommended for Western Blot applications
KAP1 is a nuclear corepressor for KRAB domain-containing zinc finger proteins. KAP1 recruits CHD3 and through this mediates gene silencing. KAP1 increases H3K9 methylation and disposes HP1 proteins to silence gene expression. Recruitment of SETDB1 by KAP1 induces heterochromatinization.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
Specifications
| Product Type: | Antibody |
| Antigen: | Phospho-KAP1, KRAB-ZFP-associated protein 1, TRIM28, TIF1B, KRAB-Associated protein 1 |
| Accession ID: | Q13263 |
| Molecular Weight: | 88 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | BK 110502 P |
| Reactivity: | Human |
| Immunogen: | phospho-peptide |
| Species Immunized: | Rabbit |
| Epitope: | phospho-Ser824 |
| Purification Method: | Affinity purified |
| Buffer: | BSA/sodium azide |
| Tested Applications: | WB (1:1000) |
| Concentration: | 0.24 mg/mL |
| Storage: | -20C, avoid freeze thaw cycles |
| Shipped: | Cold packs |
Provider
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
References
- White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 2006 Dec 15;66(24):11594-9.
- Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6841-6. doi: 10.1073/pnas.1217692110.
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