Anti-AJUBA [3198] Antibody
![Anti-AJUBA [3198] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1145_2001202001263611440.jpg "Anti-AJUBA [3198] Antibody")
This rabbit IgG polyclonal antibody was generated against LIM domain-containing protein ajuba (AJUBA) and recognizes mouse AJUBA.
Highlights:
- Recognizes mouse AJUBA
- Recommended for Western Blot, Immunoprecipitation, Immunofluorescence, and CHIP applications
AJUBA is a scaffold protein which is a part of numerous protein complexes and controls several cellular processes such as determination of cell fate, cytoskeletal organization, gene transcription, cell adhesion, differentiation, cell cycle and motility. AJUBA regulates Aurora A kinase during mitosis. AJUBA is an effector in IL-1 signaling pathway and is able to modulate IL-1-induced NFKB1 activation by regulating the integrity and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. AJUBA is a HDAC-dependent corepressor for a subset of GFI1 target genes. AJUBA downregulates E-cadherin transcription in a SNAI1 and SNAI2/SLUG-dependent manner.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
This rabbit IgG polyclonal antibody was generated against LIM domain-containing protein ajuba (AJUBA) and recognizes mouse AJUBA.
Highlights:
- Recognizes mouse AJUBA
- Recommended for Western Blot, Immunoprecipitation, Immunofluorescence, and CHIP applications
AJUBA is a scaffold protein which is a part of numerous protein complexes and controls several cellular processes such as determination of cell fate, cytoskeletal organization, gene transcription, cell adhesion, differentiation, cell cycle and motility. AJUBA regulates Aurora A kinase during mitosis. AJUBA is an effector in IL-1 signaling pathway and is able to modulate IL-1-induced NFKB1 activation by regulating the integrity and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. AJUBA is a HDAC-dependent corepressor for a subset of GFI1 target genes. AJUBA downregulates E-cadherin transcription in a SNAI1 and SNAI2/SLUG-dependent manner.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | AJUBA |
| Accession ID: | Q96IF1 |
| Molecular Weight: | 57 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | 3198 |
| Reactivity: | Mouse |
| Immunogen: | Recombinant AJUBA protein |
| Species Immunized: | Rabbit |
| Purification Method: | Affinity purified |
| Buffer: | BSA/sodium azide |
| Tested Applications: | WB (1:1000), IP, IF, CHIP |
| Concentration: | 1mg/mL |
| Storage: | -20C, avoid freeze thaw cycles |
| Shipped: | Cold packs |
- Hou Z, Peng H, White DE, Negorev DG, Maul GG, Feng Y, Longmore GD, Waxman S, Zelent A, Rauscher FJ 3rd. LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2938-43. doi: 10.1073/pnas.0908656107.
If you publish research with this product, please let us know so we can cite your paper.
