Anti-CD4 [8A5] Antibody
![Anti-CD4 [8A5] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1068_2001202001263310670.jpg "Anti-CD4 [8A5] Antibody")
This mouse IgM monoclonal antibody recognizes the amino-acid sequence corresponding to the 3'-UGA codon region of human cluster of differentiation antignen 4 (CD4).
Highlights:
- Reacts with the region of the human CD4 gene downstream of the natural UGA (STOP) codon transcribed, if termination at the UGA codon is suppressed
- Ideal for studies of the role of selenium metabolism and selenoproteins in diseases, such as infectious diseases and cancer
- Tested for Western Blot, Immunofluorescence, and ELISA applications
Eukaryotic genes end with one of three stop codons, UGA, UAA, or UAG. Of these three, UGA is unique. In addition to functioning as a stop codon, UGA is also the codon for the twenty-first amino acid, selenocysteine. The biological bases for the dual function of the UGA codon are not entirely clear. Selenocysteine plays a critical role in physiology, and perturbations of selenium intake and metabolism can have disastrous consequences. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus.
From the laboratory of Ethan W. Taylor, PhD, University of Georgia.
Part of The Investigator's Annexe program.
This mouse IgM monoclonal antibody recognizes the amino-acid sequence corresponding to the 3'-UGA codon region of human cluster of differentiation antignen 4 (CD4).
Highlights:
- Reacts with the region of the human CD4 gene downstream of the natural UGA (STOP) codon transcribed, if termination at the UGA codon is suppressed
- Ideal for studies of the role of selenium metabolism and selenoproteins in diseases, such as infectious diseases and cancer
- Tested for Western Blot, Immunofluorescence, and ELISA applications
Eukaryotic genes end with one of three stop codons, UGA, UAA, or UAG. Of these three, UGA is unique. In addition to functioning as a stop codon, UGA is also the codon for the twenty-first amino acid, selenocysteine. The biological bases for the dual function of the UGA codon are not entirely clear. Selenocysteine plays a critical role in physiology, and perturbations of selenium intake and metabolism can have disastrous consequences. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus.
From the laboratory of Ethan W. Taylor, PhD, University of Georgia.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | RFLPADQMNVADPQPLASCS of human CD4 |
| Accession ID: | P01730 |
| Isotype: | IgMk |
| Clonality: | Monoclonal |
| Clone Name: | 8A5, also known as Antibody 025 |
| Reactivity: | Human (possibly others) |
| Immunogen: | Peptide |
| Species Immunized: | Mouse |
| Purification Method: | Not purified |
| Buffer: | Cell culture supernatant |
| Tested Applications: | Use undiluted or up to 1:300. Dilute in PBS or other compatible medium as required by specific experiment. For ELISA: 10-25 ug/ml (Jurkat, H9, HeLa). For IF: 5-12 ug/ml |
| Storage: | -80C (long term) |
| Shipped: | Cold Packs |
- Ware, B.N.: Gene regulation and overlooked coding regions : the case for translation past the 3'-UGA codon in CD4. Ph.D. Thesis. University of Georgia, College of Pharmacy.(2003)
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