Human Pancreatic Duct Epithelial Cell Line (H6c7)

H6c7 is an immortalized epithelial cell line derived from normal human pancreatic duct epithelial (HPDE) cells. This cell line is an attractive model for human pancreatic duct cell carcinogenesis studies.


  • Demonstrate near normal genotype and phenotype of HPDE cells
  • Display copy number of p16INK4A gene, wild type p53 and KRAS genes
  • Morphologically similar to the primary HPDE cells, grow anchorage-dependently and do not form tumors in scid mice
  • Growth remains inhibited by transforming growth factor (TGF)-beta 1

From the laboratory of Ming-Sound Tsao, MD, FRCPC, University Health Network, Canada.

Catalog Number Product Size AVAILABILITY Price Qty
Human Pancreatic Duct Epithelial Cell Line (H6c7), 1 Vial (Non-Profit)
1 vial In stock
Price: $799.00
Human Pancreatic Duct Epithelial Cell Line (H6c7), 1 Vial (For-Profit)
1 vial In stock
Price: $1,281.00

For-profit customers must contact Kerafast first before ordering. For profit customers, please Contact Us for more information.

Product Type: Cell Line
Name: H6C7
Cell Type: Epithelial
Accession ID: CVCL_0P38
Organism: Human
Source: Pancreatic duct
Morphology: Epithelial
Biosafety Level: BSL2
Subculturing: 1:4 split
Growth Conditions: Keratinocyte serum free
Cryopreservation: Growth medium plus 10% DMSO
Mycoplasma Tested: Yes
Storage: Liquid nitrogen
Shipped: Dry ice
From the laboratory of Ming-Sound Tsao, MD, FRCPC, University Health Network, Canada.
  1. Radulovich N, Qian JY, Tsao MS. Human pancreatic duct epithelial cell model for KRAS transformation. Methods Enzymol. 2008;439:1-13.
  2. Qian J, Niu J, Li M, Chiao PJ, Tsao MS. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res. 2005 Jun 15;65(12):5045-53.
  3. Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA, Tsao MS. Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol. 1996 Jun;148(6):1763-70.
  4. Hu J, Sheng Y, Kwak KJ, Shi J, Yu B, Lee LJ. A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection. Nat Commun. 2017 Nov 22;8(1):1683. View Article
  5. Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Personalized RNA Medicine for Pancreatic Cancer. Clin Cancer Res. 2018 Apr 1;24(7):1734-1747. View Article
  6. Wei W, Liu Y, Lu Y, Yang B, Tang L. LncRNA XIST Promotes Pancreatic Cancer Proliferation Through miR-133a/EGFR. J Cell Biochem. 2017 Oct;118(10):3349-3358. View Article
  7. Tanton H, Voronina S, Evans A, Armstrong J, Sutton R, Criddle DN, Haynes L, Schmid MC, Campbell F, Costello E, Tepikin AV. F(1)F(0)-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation. Front Physiol. 2018 Jul 11;9:833. View Article
  8. Zhu G, Zhou L, Liu H, Shan Y, Zhang X. MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway. Cell Physiol Biochem. 2018 Aug 3;48(4):1735-1746. View Article
  9. Liu B, Palmfeldt J, Lin L, Colaço A, Clemmensen KKB, Huang J, Xu F, Liu X, Maeda K, Luo Y, Jäättelä M. STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH. Cell Res. 2018 Aug 20. View Article
  10. Park JY, Cho YL, Chae JR, Moon SH, Cho WG, Choi YJ, Lee SJ, Kang WJ. Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. Mol Ther Nucleic Acids. 2018 Sep 7;12:543-553. View Article

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