Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] Antibody
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This IgG1 mouse monoclonal (AP2) was generated against human glycoprotein IIIa and is specific for the beta I domain of human platelet glycoprotein IIIa (GPIIIa; CD61) only when in complex with GPIIb (CD41).
Highlights:
- Reacts with human glycoprotein IIIa
- Suitable for ELISA and Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
This IgG1 mouse monoclonal (AP2) was generated against human glycoprotein IIIa and is specific for the beta I domain of human platelet glycoprotein IIIa (GPIIIa; CD61) only when in complex with GPIIb (CD41).
Highlights:
- Reacts with human glycoprotein IIIa
- Suitable for ELISA and Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
Specifications
| Product Type: | Antibody |
| Antigen: | Glycoprotein IIb/IIa |
| Accession ID: | P08514, P05106 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | AP2 |
| Reactivity: | Human |
| Immunogen: | Human platelet |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium azide |
| Tested Applications: | Flow Cytometry (0.02 mg/mL), ELISA capture (10ug/mL) and detection (10ug/mL) |
| Storage: | -20C |
| Shipped: | Cold packs |
Research
| Antibody | Domain |
| Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
| Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
- Pidard D, Montgomery RR, Bennett JS, Kunicki TJ. Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J Biol Chem. 1983 Oct 25;258(20):12582-6.
If you publish research with this product, please let us know so we can cite your paper.
