Anti-ADAM9 (human), Cytoplasmic Domain Antibody

This rabbit IgG polyclonal antibody was generated against the GST-ADAM9-cytoplasmic tail and is specific for the cytoplasmic domain of human ADAM9.

The ADAM (A Disintegrin And Metalloprotease Domain) family is a unique group of proteins that has the ability to cleave or shed extracellular portions of transmembrane proteins. In addition, ADAMs are involved in cell-cell and cell-matrix interactions (e.g., fertilization, muscle development and neurogenesis).

ADAM9 (MDC9, meltrin gamma) is widely expressed and catalytically active. ADAM9 is highly conserved in mouse and human (82% identical). ADAM9 contains the following domains: a signal sequence followed by a prodomain, a domain with sequence similarity to snake venom metalloproteases, a disintegrin domain, a cysteine-rich region, an EGF repeat, a membrane anchor and a cytoplasmic tail. The cytoplasmic tail of ADAM9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains. To clone the full-length cDNA for human ADAM9, a human cDNA library from mammary epithelial carcinoma cells were synthesized. For experiments involving ADAM9-reactive antibodies, the antibodies were raised against the GST-ADAM9-cytoplasmic tail.

From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product Size AVAILABILITY Price Qty
EHS001
Anti-ADAM9 (human), Cytoplasmic Domain Antibody, 100uL
100uL In stock
Price: $299.00
Specifications
Product Type: Antibody
Accession ID: U41766
Antigen: GST-ADAM9 cytoplasmic domain
Molecular Weight: ~84 kDa (mature form), 115 kDa (pro-form)
Isotype: IgG
Clonality: Polyclonal
Reactivity: Human
Immunogen: GST-cyto corresponding to the cytoplasmic domain of human ADAM9
Species Immunized: Rabbit
Epitope: Cytoplasmic domain
Purification Method: Serum, not purified
Tested Applications: WB (1:1000)
Storage: -80C
Shipped: Dry ice
Research
Antibody Species Reactivity Specificity
ADAM9 Human Cytoplasmic Domain
ADAM9 Mouse Cytoplasmic Domain
ADAM12 Mouse Cytoplasmic Domain
ADAM15 Human Cytoplasmic Domain
ADAM15 Mouse Cytoplasmic Domain
ADAM15 Human Extracellular Domain
ADAM15 Mouse Disintegrin Domain
ADAM17 Mouse Cytoplasmic Domain
ADAM17 Mouse Pro domain
ADAM19 Mouse Cytoplasmic Domain
ADAM28 Mouse Cytoplasmic Domain
ADAM28 Mouse Extracellular Domain
SNX9 Mouse Cytoplasmic Domain
Data

Western Blot Analysis

Adapted from: Weskamp G, et al. J Cell Biol. 1996 Feb;132(4):717-26.

Provider
From the laboratory of Carl P. Blobel, MD, PhD, Hospital for Special Surgery.
References
  1. Weskamp G, Krätzschmar J, Reid MS, Blobel CP. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J Cell Biol. 1996 Feb;132(4):717-26.

If you publish research with this product, please let us know so we can cite your paper.

 
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