Cyclopamine

Cyclopamine is a steroidal alkaloid isolated from the corn lily that is an antagonist of the Sonic Hedgehog gene pathway with potential anticancer properties.

Cyclopamine is a teratogen that causes fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). Cyclopamine acts as a primary inhibitor of the so-called "hedgehog" signal-transduction pathway in cells. Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the smoothened protein. This pathway, named for the ligand for the signal protein, is used by cells to help them react to external chemical signals. The pathway carries out important functions in embryonic development and when it goes awry, deformities can occur. Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is over-expressed.

Catalog Number Product Size AVAILABILITY Price Qty
FAP021
Cyclopamine, 1mg
1mg 1-2 weeks
Price: $105.00
FAP022
Cyclopamine, 5mg
5mg 1-2 weeks
Price: $400.00
Specifications
Product Type: Small Molecule
Chemical Formula: C27H41NO2
CAS number: 4449-51-8
Molecular Weight: 411.62
Format: White to off-white crystals
Purity: >99 % determined by HPLC
Solubility: Soluble in DMSO (6 mg/mL), Water (1 mg/mL), and Ethanol (39 mg/mL)
Stability: Stable as a solid over extended period at -20C.
Storage: -20C
Shipped: Cold Pack
Data

Cyclopamine HPLC Chromatogram.


Purification Notes: Cyclopamine is manufactured using near-critical and supercritical fluid phase extraction and segmentation chromatography.

References
  1. Bradley D. (2009). Keeping an eye on anticancer drug. NMR Knowledge Base.
  2. Herper M. (2005). The Curious Case of The One-Eyed Sheep Forbes.com.
  3. Pipeline: IPI-926. Infinity Pharmaceuticals.
  4. Taipale J; Chen J, Cooper M, Wang B, Mann R, Milenkovic L, Scott M and Beachy P. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature PubMed. 406 (6799): 1005–9. Doi:10.1038/35023008. PMID 10984056.

If you publish research with this product, please let us know so we can cite your paper.

 
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