This IgG1 mouse monoclonal antibody [VIA41] is reactive against alpha dystroglycan.
Dystroglycan is one of the dystrophin-associated glycoproteins that acts as a transmembrane link between the extracellular matrix and the cytoskeleton. They are involved in a number of processes such as lamnin and basement membrane assembly, sacrolemmal stability, cell survival, nerve myelination, nodal structure, cell migration and epithelial polarization. Specifically, alpha dystroglycan (an extraceullular glycoprotein) acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses.
From the laboratory of Kevin P. Campbell, PhD, University of Iowa.
Part of The Investigator's Annexe program.
|Alternative Name(s):||Dystrophin-associated glycoprotein 1|
|Molecular Weight:||156 kDa|
|Reactivity:||Human, mouse and rabbit|
|Immunogen:||Rabbit sarcolemma membranes|
|Epitope:||Carbohydrate structure on alpha-DG|
|Buffer:||Cell culture supernatant|
|Tested Applications:||IF (1:20), WB (1:100)|
|Storage:||4C short term, -80C long term (avoid freeze-thaw cycles)|
Western blot of muscle membrane
Western blot showing monoclonal antibody VIA41 against SL156. Lanes 1-4 are KCL washed microsomes, light microsomes, pellet from the sucrose density step gradient and crude surface membranes from rabbit skeletal muscle. Molecular weight markers on the left.Adapted from: Ohlendieck, K. et al., J. Cell Biol. 112 :135-148, 1991.
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