This IgG monoclonal antibody was generated against methylglyoxal (MG)-modified ovalbumin, and is reactive against human, mouse and rat MG.
Recombinant versions available at our sister company, Absolute Antibody:
Methylglyoxal (MG) also referred to as pyruvaldehyde or 2-oxopropanal is formed as a side product of several metabolic pathways. Importantly, it has shown to be involved in the formation of advanced glycation end products otherwise known as AGEs. AGEs are formed both outside and inside the body. AGEs are substances that can be a factor in the development or worsening of many degenerative diseases including Diabetes and Alzheimer's disease.
From the laboratory of Helen Vlassara, MD, Icahn School of Medicine at Mount Sinai
Part of The Investigator's Annexe program.
|Name:||Anti-Advanced Glycation End products (AGE), Methylglyoxal (MG) - AGE-MG [3D11] Antibody|
|Molecular Weight:||45.4 kDa|
|Reactivity:||Human, Mouse, Rat|
|Purification Method:||Protein G Affinity Chromatography|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB (1:800-2000), IHC (1:10-20), ELISA (1:1000)|
Binding inhibition curve of anti-MG derivative (MG3D11)
Affinity of mouse monoclonal antibody (MG3D11) was determined by a competitive ELISA. Competitive inhibition of antibody binding by modified and unmodified proteins (left) or lipid lipoprotein preparations (right)
Adapted from: Cai W., et. al Mol Med 8: 337-346, 2002.
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