Anti-MHC Class I H2 Kb [AF6-88.5.5.3] Antibody
This mouse IgG2a monoclonal antibody was generated against H-2Kb, and recognizes mouse H2Kb MHC Class I.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AF6-88.5.5.3.
MHC Class I H-2 Kb is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.
From a laboratory at University of Chicago.
This mouse IgG2a monoclonal antibody was generated against H-2Kb, and recognizes mouse H2Kb MHC Class I.
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AF6-88.5.5.3.
MHC Class I H-2 Kb is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells, but expression varies on different cell types. MHC Class I molecules present intracellular processed peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. This results in a cytoxic effector response against the presenting cell. Additionally, MHC Class I antigens are expressed on thymic epithelial cells, which is an important regulation step during the positive and negative selection of CD8+ T cells during T cell ontogeny.
From a laboratory at University of Chicago.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Mouse H-2Kb MHC Class I (AF6-88.5.5.3) |
| Accession ID: | O19468 |
| Host: | Mouse |
| Isotype: |
EZ1002: IgG2a Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | AF6-88.5.5.3 |
| Specificity: | This antibody recognizes mouse H-2Kb MHC Class I |
| Immunogen: | H-2Kb |
| Format: | Liquid |
| Purification Method: | Protein G purified |
| Buffer: |
EZ1002: PBS with 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | Immunofluorescence, flow cytometry, immunoprecipitation, immunohistology |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | Store at 4C |
| Shipped: | Cold packs |
- Wall, K.A., et al. Inhibition of Proliferation of Mis- and la-Reactive Cloned T Cells by a Monoclonal Antibody Against a Determinant Shared by I-A and LE. The Journal of Immunology. 131(3): 1056 - 1064. 1983.
If you publish research with this product, please let us know so we can cite your paper.
