Anti-OxPL [10C12] Antibody

This mouse IgM Kappa monoclonal antibody was generated from spleens of ApoE KO mice fed a high-fat Western diet (for 7 months), and is specific to oxidized phospholipids POVPC and PGPC.

Highlights:

  • Reacts with oxidized phospholipids POVPC and PGPC
  • Suitable for Immunohistochemistry and ELISA applications

Phospholipids are a crucial component of all cell membranes. They are composed of a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue. Their application can be found to be very useful in nanotechnology and material science, as purified phospholipids can be produced commercially. Oxidized phospholipids (such as the derivatives POVPC and PGPC) play an important role in cardiovascular diseases, as well as inflammation.

From a laboratory at University of Virginia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EG1050
Anti-OxPL [10C12] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Name: Anti-OxPL [10C12] Antibody
Antigen: OxPL
Isotype: IgM Kappa (Mouse)
Clonality: Monoclonal
Clone Name: 10C12
Immunogen: POVPC/PGPC (OxPL)
Species Immunized: Mouse
Purification Method: Protein A or A/G affinity purified
Buffer: PBS, 0.05% Sodium Azide
Tested Applications: IHC, ELISA
Storage: -20C
Shipped: Cold packs

Provider
From a laboratory at University of Virginia.
References
  1. Cherepanova OA, Owens GK. Abstract 622: Development of an antioxidized phospholipid neutralizing antibody as an atheroprotective therapeutic agent. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(suppl_1).
  2. Cherepanova OA, Srikakulapu P, Greene ES, Chaklader M, Haskins RM, McCanna ME, Bandyopadhyay S, Ban B, Leitinger N, McNamara CA, Owens GK. Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):206-219. doi: 10.1161/ATVBAHA.119.312771. Epub 2019 Oct 24. PMID: 31645128; PMCID: PMC7006879.

If you publish research with this product, please let us know so we can cite your paper.

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