Anti-MARCO [PLK1] Antibody
![Anti-MARCO [PLK1] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1046_2001202001263210450.jpg "Anti-MARCO [PLK1] Antibody")
This mouse monoclonal IgG3 antibody, MARCO [PLK1], was raised against human alveolar macrophages (AMs) and recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples.
Highlights:
- Recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples
- Suitable for flow cytometry, IP, WB, IF, IHC-Fr applications
Macrophage Receptor With Collagenous Structure (MARCO) is encoded by MARCO gene, and is a member of the class A scavenger receptor family. This transmembrane protein is found in certain subtypes of macrophages and plays a key role in innate immune tolerance by scavenging or clearing the pathogens and thus leading to inflammatory responses (mediates binding of unopsonized particles by alveolar macrophages). MARCO is associated with several diseases, such as Alzheimer's disease, Igg4-Related Disease and Bacterial Pneumonia. It has also been studied in oncology as a potentially attractive target for immunotherapy.
From the laboratory of Lester Kobzik, MD , Harvard University.
This mouse monoclonal IgG3 antibody, MARCO [PLK1], was raised against human alveolar macrophages (AMs) and recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples.
Highlights:
- Recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples
- Suitable for flow cytometry, IP, WB, IF, IHC-Fr applications
Macrophage Receptor With Collagenous Structure (MARCO) is encoded by MARCO gene, and is a member of the class A scavenger receptor family. This transmembrane protein is found in certain subtypes of macrophages and plays a key role in innate immune tolerance by scavenging or clearing the pathogens and thus leading to inflammatory responses (mediates binding of unopsonized particles by alveolar macrophages). MARCO is associated with several diseases, such as Alzheimer's disease, Igg4-Related Disease and Bacterial Pneumonia. It has also been studied in oncology as a potentially attractive target for immunotherapy.
From the laboratory of Lester Kobzik, MD , Harvard University.
| Product Type: | Antibody |
| Name: | Anti-MARCO [PLK1] Antibody |
| Alternative Name(s): | macrophage receptor MARCO; macrophage receptor with collagenous structure; scavenger receptor class A member 2; SCARA2 |
| Antigen: | MARCO |
| Accession ID: | Q9UEW3 |
| Molecular Weight: | 52kD |
| Isotype: | IgG3 |
| Clonality: | Monoclonal |
| Clone Name: | PLK-1 |
| Reactivity: | Human and bovine MARCO |
| Specificity: | Extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples |
| Immunogen: | Human Alveolar Macrophages |
| Species Immunized: | Mouse, BALB/c |
| Epitope: | Extracellular domain V between residues 420 and 431 |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | Flow Cytometry, IP, WB, IF, IHC-Fr |
| Concentration: | 1mg/mL |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005 Nov 1;175(9):6058-64. doi: 10.4049/jimmunol.175.9.6058. PMID: 16237101.
- Palecanda A, Kobzik L. Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. Curr Mol Med. 2001 Nov;1(5):589-95. doi: 10.2174/1566524013363384. PMID: 11899233.
- Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S. Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J Pathol. 2006 Mar;208(4):574-89. doi: 10.1002/path.1921. PMID: 16440291.
- Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA. Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013 Jun 15;190(12):6360-7. doi: 10.4049/jimmunol.1202942. Epub 2013 May 10. PMID: 23667110; PMCID: PMC3679202.
- Dahl M, Bauer AK, Arredouani M, Soininen R, Tryggvason K, Kleeberger SR, Kobzik L. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest. 2007 Mar;117(3):757-64. doi: 10.1172/JCI29968. PMID: 17332894; PMCID: PMC1804372.
If you publish research with this product, please let us know so we can cite your paper.
