Insulin-like growth factor-binding proteins (IGFBPs) are involved in mediating the effects of insulin-like growth factor (IGF) actions in a wide variety of cell types. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Insulin-like growth factor binding protein 3 (IGFBP-3) is the main carrier of IGF in the body and is complexed with roughly 80% of the serum IGFs. IGFBP-3 helps extend the life of IGF in the blood and helps control its effects on body tissues. Levels of IGFBP-3 are highest during childhood and puberty, and then decrease during adulthood. Levels also may be affected by sexual maturation and nutritional status.
Sample Requirements: Serum or Plasma (EDTA), Cell Culture Supernatants
Minimum Sample Volume: 50uL
From the laboratory of Clifford J. Rosen, PhD, Maine Medical Center Research Institute.
Part of The Investigator's Annexe program.