Insulin-like growth factor 1 (IGF-1) or as it’s also known as, somatomedin C, is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by under nutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor. IGF-1 is a primary mediator of the effects of growth hormone (GH). Its primary action is mediated by binding the Insulin-like growth factor 1 receptor, a receptor tyrosine kinase.
Sample Requirements: Serum or Plasma (EDTA or Heparin)
Minimum Sample Volume: 200uL
From the laboratory of Clifford J. Rosen, PhD, Maine Medical Center Research Institute.
Part of The Investigator's Annexe program.