Carboxy-terminal collagen crosslinks (CTx) are peptide fragments generated by collagen degradation, and have been shown to be more specific to bone resorption than other measurements. CTx is analyzed using the CrossLaps assay which detects collagen type I fragments and employs monoclonal antibodies recognizing C-telopeptide fragments of collagen type I.
The CTX-I assay is based on chemiluminescence technology. Two highly specific monoclonal antibodies are used. The antibodies are against the amino acid sequence of EKAHD-ß-GGR, where the aspartic acid residue is (D) ß-isomerized. In order to obtain a specific signal in IDS iSYS CTX-I assay, two chains of of EKAHD-ß-GGR must be cross-linked.
Sample Requirements: Serum or Plasma (EDTA, Citrate or Heparin)
Minimum Sample Volume: 200uL
From the laboratory of Clifford J. Rosen, PhD, Maine Medical Center Research Institute.
Part of The Investigator's Annexe program.