This mouse IgG2a monoclonal antibody recognizes human and mouse CHD4 and was generated against synthetic N- and C-terminal peptides of the CHD4 protein.
CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Accumulating evidence indicates that NuRD may regulate the transcription of specific genes by interacting with specific transcriptional factors. In addition, the NuRD complex may also participate in genome-wide transcriptional regulation through an association with histone tails.
From a laboratory at Cancer Research Technology.
Part of The Investigator's Annexe program.
|Immunogen:||Synthetic peptide (N- and C- terminal peptides were used for immunization. 1. ASGLGSPSPCSAGSEEEDM & 2. CSRLANRAPEPPPQQVAQQQ. Which peptide the antibody recognises has not been tested)|
|Purification Method:||Protein A or A/G affinity purified|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||ChIP, ELISA, Immunoprecipitation, WB|
|Storage:||Store at -20C|
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