Anti-VSV-M [23H12] Antibody

This monoclonal antibody reacts with VSV-M protein.

Highlights:

  • Reacts with VSV-M protein
  • Suitable for Western Blot applications

Recombinant versions available from our sister company, Absolute Antibody:

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EB0011
Anti-VSV-M [23H12] Antibody
100ug (1mg/mL) In stock
Regular Price:$345.00
On Sale:
Kf-Ab01404-10.0
Recombinant Anti-VSV-M [23H12], Human, IgG1k
200ug In stock
Regular Price:$470.00
On Sale:
Kf-Ab01404-10.3
Recombinant Anti-VSV-M [23H12], Human, IgG1k
200ug 4-5 weeks
Regular Price:$470.00
On Sale:
Kf-Ab01404-15.0
Recombinant Anti-VSV-M [23H12], Human, IgMk
50ug 4-5 weeks
Regular Price:$630.00
On Sale:
Kf-Ab01404-2.0
Recombinant Anti-VSV-M [23H12], Mouse, IgG2ak
200ug 4-6 weeks
Regular Price:$470.00
On Sale:
Kf-Ab01404-2.3
Recombinant Anti-VSV-M [23H12], Mouse, IgG2ak
200ug In stock
Regular Price:$470.00
On Sale:
Kf-Ab01404-21.0
Recombinant Anti-VSV-M [23H12], Mouse, IgMk
50ug 4-5 weeks
Regular Price:$630.00
On Sale:
Kf-Ab01404-23.0
Recombinant Anti-VSV-M [23H12], Rabbit, IgGk
200ug In stock
Regular Price:$470.00
On Sale:
Specifications

Product Type: Antibody
Name: Anti-VSV-M [23H12]
Antigen: VSV-M
Accession ID: P03519
Host: Mouse
Isotype: EB0011: IgG2a kappa
Recombinant versions: see product name
Clonality: Monoclonal
Clone Name: 23H12
Specificity: VSV-Ind matrix (M) protein
Reactivity: Human
Immunogen: VSV infection
Format: Liquid
Purification Method: Protein G purified
Buffer: EB0011: PBS, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
Tested Applications: Western blot (1:1000)
Concentration: 1mg/mL
Amount: 100uL
Storage: -20C (avoid repeated freeze / thaw cycles)
Shipped: Cold packs

Provider
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
References
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  2. Lefrancios L, Lyles DS. The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies. Virology 121: 157-167, 1982.
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  18. Brinkmann C, Hoffmann M, Lübke A, Nehlmeier I, Krämer-Kühl A, Winkler M, Pöhlmann S. The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells. PLoS One. 2017 Dec 7;12(12):e0189073. View Article
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  24. González-Hernández M, Hoffmann M, Brinkmann C, Nehls J, Winkler M, Schindler M, Pöhlmann S. A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism. J Virol. 2018 Jun 13;92(13). pii: e00403-18. View Article
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