Synthetic peptides corresponding to Guinea pig gonadotropin realeasing hormone (GnRH).
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.
|Amino Acid Sequence:||pGlu-Tyr-Trp-Ser-Tyr-Gly-Val-Arg-Pro-Gly|
|Purity:||Greater than 95% by HPLC (Protein Core Facility in the Department of Physiology at Tufts Medical School)|
|Comments:||Synthesis was performed using Fast Moc TM chemistry on a model 431A, version 1.12 software, synthesizer (Applied Biosystems). The peptide was cleaved from the resin using a mixture of phenol, ethanedithiol, thioanisole, and trifluoroacetic acid. Samples were purified, reconstituted, and sent for Matrix-assisted laser desorption / ionization mass spectrum (HT laboratories, San Diego) for confirmation of peptide synthesis.|
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