Anti-Kai1 (CD82) [M35] Antibody
![Anti-Kai1 (CD82) [M35] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1393_2001202001264613920.jpg "Anti-Kai1 (CD82) [M35] Antibody")
This rabbit polyclonal antibody was generated against a synthetic peptide corresponding to mouse Kai1/CD82 (135-SREEAWDYVQAQVKC-149) and recognizes mouse and rat Kai1/CD82.
Highlights:
- Reacts with mouse and rat Kai1/CD82
- Suitable for Western Blot, Immunohistochemistry and flow cytometry applications
Kia1 (CD82) has been shown to associate with CD4 and CD8, and delivers costimulatory signals for the TCR/CD3 pathway.This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
From the laboratory of Mary Custer, National Cancer Institute/NIH.
This rabbit polyclonal antibody was generated against a synthetic peptide corresponding to mouse Kai1/CD82 (135-SREEAWDYVQAQVKC-149) and recognizes mouse and rat Kai1/CD82.
Highlights:
- Reacts with mouse and rat Kai1/CD82
- Suitable for Western Blot, Immunohistochemistry and flow cytometry applications
Kia1 (CD82) has been shown to associate with CD4 and CD8, and delivers costimulatory signals for the TCR/CD3 pathway.This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
From the laboratory of Mary Custer, National Cancer Institute/NIH.
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| Product Type: | Antibody |
| Antigen: | murine Kai1/CD82 |
| Accession ID: | P40237, D14883.1 |
| Host: | Rabbit |
| Molecular Weight: | 50-64 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Clone Name: | M35 |
| Reactivity: | Mouse, rat |
| Immunogen: | Synthetic peptide corresponding to mouse Kai1/CD82 (135-SREEAWDYVQAQVKC-149) |
| Purification Method: | Affinity chromatography |
| Buffer: | Whole serum |
| Tested Applications: | WB, IHC, Flow Cytometry (See: Custer MC, et al. The Prostate 66(6):567-77, 2006.) |
| Concentration: | 0.91mg/mL |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Custer, M.C., Risinger, J.I., Simpson, R.M., Hoover, S., Patterson, T., Barrett, J.C.: Characterization of an Antibody That Can Detect the Murine Metastasis Suppressor Gene, Kai 1. The Prostate 66(6):567-77, 2006.
- Bergsma A, Ganguly SS, Wiegand ME, Dick D, Williams BO, Miranti CK. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82. Bone Rep. 2019 Jan 30;10:100196. View Article
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