Anti-Biglycan (Mouse/Rat) [LF-159] Antibody

This rabbit IgG polyclonal antibody was raised against peptide and recognizes mouse and rat biglycan.

Highlights:

  • Recognizes mouse and rat biglycan - Epitope -amino acid sequence VPDLDSVTPTFSAMC
  • Suitable for Immunohistochemistry and Western Blot applications

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans it is encoded by the BGN gene located on the X chromosome and is mainly involved in collagen fiber assembly.

From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.

 

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH020-FP
Anti-Biglycan (Mouse/Rat) [LF-159] Antibody
100uL In stock
Regular Price:$306.00
On Sale:

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Specifications

Product Type: Antibody
Alternative Name(s): Bone/cartilage proteoglycan I, PG-S1
Antigen: Biglycan
Molecular Weight: 39871 Da
Isotype: IgG
Clonality: Polyclonal
Clone Name: LF-159
Reactivity: Mouse and Rat
Immunogen: Peptide
Species Immunized: Rabbit
Epitope: VPDLDSVTPTFSAMC
Buffer: Whole serum
Tested Applications: WB (1:1000), IHC (1:200)
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
References
  1. Fisher LW, Stubbs JT 3rd, Young MF. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop Scand Suppl. 1995 Oct;266:61-5.
  2. von Marschall Z, Fisher LW. Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1). Biochem Biophys Res Commun. 2010 Jan 15;391(3):1374-8. doi: 10.1016/j.bbrc.2009.12.067.
  3. Fust A, LeBellego F, Iozzo RV, Roughley PJ, Ludwig MS. Alterations in lung mechanics in decorin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L159-66.
  4. Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U. Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar 21;14(3):e1007242. View Article
  5. Li C, Jing Y, Wang K, Ren Y, Liu X, Wang X, Wang Z, Zhao H, Feng JQ. Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process. Int J Biol Sci. 2018 Apr 30;14(7):693-704. View Article
  6. Hua R, Ni Q, Eliason TD, Han Y, Gu S, Nicolella DP, Wang X, Jiang JX. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix Biol. 2020 Sep 28:S0945-053X(20)30089-5. View article

If you publish research with this product, please let us know so we can cite your paper.

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