This mouse IgG2a monoclonal antibody was generated against flavivirus envelope proteins and recognizes the domain II of protein E (fusion loop) of flavivirus.
The flavivirus inlcudes West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis. Flaviviruses have a (+) sense RNA genome and replicate in the cytoplasm of the host cells. The genome mimics the cellular mRNA molecule in all aspects except for the absence of the poly-adenylated (poly-A) tail. This feature allows the virus to exploit cellular apparatus to synthesise both structural and non-structural proteins, during replication.
|Antigen:||Flavivirus Envelope (E) Protein|
|Immunogen:||Flavivirus envelope proteins|
|Purification Method:||Protein G|
|Buffer:||PBS, pH 7.2|
Detection of ZIKV via immunofluorescence
Sample confocal images of forebrain-specific hNPCs 56 hr after infection with ZIKV supernatant, immunostained for ZIKV envelop protein (ZIKVE; green) and DAPI (gray). Cells were differentiated from the C1-2 hiPSC line. Scale bars, 20 ?m.
Adapted from: Tang H, et al. Cell Stem Cell. 2016 May 5;18(5):587-90.
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