Pradip Raychaudhuri, PhD, University of Illinois at Chicago

Pradip Raychaudhuri, PhD
Pradip Raychaudhuri, PhD

The Raychaudhuri is interested in the cell cycle regulators (both positive and negative) that are involved in oncogenesis and tumor suppression. Currently, they are studying the roles of the cell cycle transcription factor FoxM1 in tumor development and tumor metastasis. Also, they are studying DDB2, which was identified as a DNA repair protein, to investigate how it participates in the pathways of DNA damage response and premature senescence.

Products

References

  1. Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. 2015 Jun 4;58(5):794-803.
  2. Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, Raychaudhuri P. Proliferation defects and genome instability in cells lacking Cul4A. 2009 Jul 2;28(26):2456-65.
  3. Kopanja D, Roy N, Stoyanova T, Hess RA, Bagchi S, Raychaudhuri P. Cul4A is essential for spermatogenesis and male fertility. 2011 Apr 15;352(2):278-87.
  4. Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, Raychaudhuri P. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006 Apr;26(7):2531-9.
  5. Nag A, Bagchi S, Raychaudhuri P. Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res. 2004 Nov 15;64(22):8152-5.
  6. Shiyanov P, Nag A, Raychaudhuri P. Cullin 4A associates with the UV-damaged DNA-binding protein DDB. J Biol Chem. 1999 Dec 10;274(50):35309-12.
  7. Nag A, Bondar T, Shiv S, Raychaudhuri P. The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol Cell Biol. 2001 Oct;21(20):6738-47.
  8. Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, Costa RH. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol. 2005 Dec;25(24):10875-94.