Clifford J. Rosen, MD, Maine Medical Center Research Institute

Clifford J. Rosen, MD
Clifford J. Rosen, MD

Dr. Clifford J. Rosen, M.D. is the Director of Clinical and Translational Research and a Senior Scientist at Maine Medical Center's Research Institute. His other current positions include Adjunct Staff Scientist at the Jackson Laboratory, and Professor of Medicine at Tufts University School of Medicine. Dr. Rosen is the founder and Former Director of the Maine Center for Osteoporosis Research and Education. He was the first Editor-in-Chief of the Journal of Clinical Densitometry, is the current Editor-in-Chief of The Primer in Metabolic Bone Diseases, and just began a term as Associate Editor for JCEM. His publications include more than 300 peer-reviewed manuscripts, covering both clinical and basic bone biology.

The primary focus of the Rosen laboratory research is the genetic regulation of insulin-like growth factor relative to skeletal metabolism and the relationship between marrow adipogenesis and osteoblastogenesis. The Clinical and Translational Laboratory Services (CTRLS), a fee for service laboratory established by Dr Rosen, provides laboratory testing for biomarkers of bone and fat metabolism and disease in human and murine samples. Testing is performed either by manual immunoassay (ELISA), using commercially available kits, or on the ISYS Autoanalyzer (Immunodiagnostics Systems). The laboratory is managed by Anne Breggia, PhD and staffed by three research technologists with more than 50 years of combined experience in laboratory testing, assay development and validation.

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  1. Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring). 2011;19(1):49-53.
  2. Beamer WG, Shultz KL, Coombs HF, 3rd, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, et al. BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res. 2011;26(1):88-99.
  3. Courtland HW, Sun H, Beth-On M, Wu Y, Elis S, Rosen CJ, et al. Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production. J Bone Miner Res. 2011;26(4):761-8.
  4. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53-8. PMCID: 3046611.
  5. Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, et al. Determinants of bone mineral density in obese premenopausal women. Bone. 2011;48(4):748-54. PMCID: 3073669.
  6. Kawai M, Modder UI, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov. 2011;10(2):141-56. PMCID: 3135105.
  7. Shai SY, Sukhanov S, Higashi Y, Vaughn C, Rosen CJ, Delafontaine P. Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice. Am J Physiol Heart Circ Physiol. 2011;300(5):H1898-906. PMCID: 3094094.
  8. Cohen A, Recker RR, Lappe J, Dempster DW, Cremers S, McMahon DJ, et al. Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density. Osteoporos Int. 2011.
  9. Elis S, Wu Y, Courtland HW, Sun H, Rosen CJ, Adamo ML, et al. Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression. Aging Cell. 2011;10(3):547-50. PMCID: 3094487.
  10. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know. J Am Diet Assoc. 2011;111(4):524-7.
  11. Courtland HW, Elis S, Wu Y, Sun H, Rosen CJ, Jepsen KJ, et al. Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner. PLoS One. 2011;6(3):e14762. PMCID: 3060807.