Robert A. Nicholas, PhD, University of North Carolina Chapel Hill

Robert A. Nicholas
Robert A. Nicholas, PhD

The Nicholas lab is interested in P2Y Receptors. Specificially the regulation of P2Y Receptor signaling in platelets and signaling mechanisms of P2Y receptors. They are also interested in antibiotic resistance inNeisseria gonorrhoeae; 1) Mechanisms of chromosomally mediated antibiotic resistance. 2) Biological fitness consequences of acquiring resistance to cephalosporins and compensatory mutations that increase fitness. 3) Development of inhibitors of lipid A biosynthesis for treatment of N. gonorrhoeae.

Products

References

  1. Filtz, T, Q Li, JL Boyer, RA Nicholas, and TK Harden (1994) Cloning, expression, and pharmacological characterization of a P2Y-purinergic receptor from turkey brain. Mol Pharm, 46:8-14.
  2. Schachter, J, Li, Q, Boyer, J, Nicholas, RA, and Harden, TK (1996) Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Brit J Pharmacol, 118:167-173.
  3. Nicholas, RA, Watt, WC, Lazarowski, ER, Li, Q, and Harden, TK (1996) The uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDP-selective, a UTP-selective, and an adenine and uridine triphosphate-specific receptor. Mol Pharmacol, 50:224-229.
  4. Kennedy, C, Qi, A-D, Herold, CL, Harden, TK and Nicholas, RA (2000) ATP, an agonist at the rat P2Y4 receptor, is an anatagonist at the human P2Y4 receptor. Mol Pharmacol 57:926-931.
  5. Qi, A-D, Kennedy, C, Harden, TK and Nicholas, RA (2001) Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase. Brit J Pharmacol 132: 318-326.
  6. Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43.
  7. Lazarowski ER, Harden TK. UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation. Mol Pharmacol. 2015 Jul;88(1):51-60.