Jun Yong Kang, PhD, University of Nevada Las Vegas

Jun Yong Kang, PhD
Jun Yong Kang, PhD

Research interests in the Kang Lab include the development and synthesis of novel organocatalysts, new reaction discovery, synthesis of biologically active organic compounds and biocompatible biomaterials. Especially, N-heterocyclic phosphine (NHP) will be used as a platform for the synthesis of highly efficient bi-functional organocatalysts. The organocatalysts will be employed for the discovery of new cascade reactions such as asymmetric tandem annulation reaction via new mode of reactivity, asymmetric fluorination and the synthesis of biocompatible polymers through Ring-opening polymerization. The developed methodologies will be future applied to the synthesis of biologically active complex molecules.

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References

  1. Mulla, K.; Aleshire, K. L.;Forster, P. M. “Utility of Bi-Functional N-Heterocyclic Phosphine (NHP)-Thioureas for Metal-Free Carbon-Phosphorus Bond Construction toward Regio-, and Stereoselective Formation of Vinylphosphonates” Kang, J. Y. J. Org. Chem. 2016, 81, 77−88.
  2. Mulla, K.; Kang, J. Y. “1,3,2-Diazaphospholidine (N-Heterocyclic Phosphine)-Mediated Carbon-Phosphorus Bond Forming One-Pot Tandem Reaction: A Route to α-amino Phosphonates” J. Org. Chem. 2016, 81, 4550-4558.
  3. Huang, H.; Kang, J. Y. “Amine-Catalyzed Phospha-Michael Reaction of α,β-Unsaturated Aldehydes and Ketones with Multifunctional N-Heterocyclic Phosphine-Thioureas as Phosphonylation Reagent” Org. Lett. 2016, 18, 4372–4375.
  4. Moletti, N.; Kang, J. Y. “Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea” Org. Biomol. Chem. 2016, 14, 8952-8956.
  5. Moletti, N.; Bjornberg, C.; Kang, J. Y. “Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives” Org. Biomol. Chem. 2016, 14, 10695-10704.
  6. Huang, H.; Palmas, J.; Kang, J. Y. “A Reagent-Controlled Phospha-Michael Addition Reaction of Nitroalkenes with Bifunctional N-Heterocyclic Phosphine (NHP)-Thioureas” J. Org. Chem. 2016, 81, 11932–11939.
  7. Moletti, N.; Kang, J. Y. “Synthesis of Diaryl-Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine-Thioureas” Org. Lett. 2017, 19, 958–961.
  8. Huang, H.; Kang, J. Y., “Mitsunobu Reaction Using Basic Amines as Pronucleophiles” J. Org. Chem. 2017, 82, 6604-6614.
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