Robert W. Sobol, PhD, National Institute of Environmental Health Sciences/NIH*

Robert W. Sobol, PhD
Robert W. Sobol, PhD

Research in the Sobol lab focuses on the mechanism of base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism.

*Now affiliated with University of South Alabama.

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References

  1. Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH: Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses. J Biol Chem 2003, 278(41):39951-39959.
  2. Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R: Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. Journal of Clinical Investigation 2004, 113(12):1711-1721.