Margarita Gutova, MD, City of Hope

Margarita Gutova, MD
Margarita Gutova, MD

Studies in the Gutova laboratory are focused on the development of a novel neural stem cell lines and stem cell-mediated therapies for diseases and disorders of the central nervous system (CNS). Currently, they are working on the development of therapies for pediatric brain tumors and traumatic brain injury. However, neural stem cells could ultimately be a tool for development of new therapies for any CNS cancer or to other disorders such as neonatal ischemia, brain damage, Parkinson's disease, and stroke.

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References

  1. Rockne RC, Adhikarla V, Tsaturyan L, Li Z, Masihi MB, Aboody KS, Barish ME, Gutova M. Long-term stability and computational analysis of migration patterns of L-MYC immortalized neural stem cells in the brain. PLoS One. 2018 Aug 2;13(8):e0199967. doi: 10.1371/journal.pone.0199967. eCollection 2018. PubMed PMID: 30071048.
  2. Li Z, Oganesyan D, Mooney R, Rong X, Christensen MJ, Shahmanyan D, Perrigue PM, Benetatos J, Tsaturyan L, Aramburo S, Annala AJ, Lu Y, Najbauer J, Wu X, Barish ME, Brody DL, Aboody KS, Gutova M. L-MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells. Stem Cell Reports. 2016 Sep 13;7(3):483-95. doi: 10.1016/j.stemcr.2016.07.013. Epub 2016 Aug 18. PubMed PMID: 27546534; PubMed Central PMCID: PMC5031988.